Robinson A E, Holder A T, McDowall R D, Powell R, Sattar H
Forensic Sci. 1977 Jan-Feb;9(1):53-62. doi: 10.1016/0300-9432(77)90067-x.
Toxicological data for orphenadrine in ten cases of fatal poisoning are presented together with results for a further eight cases in which orphenadrine was present in combination with alcohol or another drug. Collapse and convulsions occur within an hour of ingestion of an overdose and death supervenes soon after. Autopsy blood concentrations of orphenadrine in such acute fatal poisonings range from 5.5-37 mug/ml. The unchanged drug was found in the bile and urine and the concentrations in the liver, lung and kidney, though differing between cases, were of the same order in any one case.
本文呈现了10例含邻甲苯海明致死中毒案例的毒理学数据，以及另外8例邻甲苯海明与酒精或其他药物混合中毒案例的结果。过量摄入后一小时内会出现虚脱和惊厥，随后很快死亡。此类急性致死中毒案例中，尸检时邻甲苯海明的血药浓度范围为5.5 - 37微克/毫升。在胆汁和尿液中发现了未代谢的药物，肝脏、肺和肾脏中的浓度虽因案例而异，但在任何一个案例中都处于同一水平。
