KIR 基因多态性与 COVID-19 疾病的关联。
Association of KIR gene polymorphisms with COVID-19 disease.
机构信息
Department of Pathology and Laboratory Medicine, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Saudi Stem Cells Donor Registry, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
出版信息
Clin Immunol. 2022 Jan;234:108911. doi: 10.1016/j.clim.2021.108911. Epub 2021 Dec 18.
BACKGROUND
Natural killer (NK) cells play an essential role against viruses. NK cells express killer cell immunoglobulin-like receptors (KIRs) which regulate their activity and function. The polymorphisms in KIR haplotypes confer differential viral susceptibility and disease severity caused by infections. We investigated the association between KIR genes and COVID-19 disease severity.
METHODS
424 COVID-19 positive patients were divided according to their disease severity into mild, moderate and severe. KIR genes were genotyped using next generation sequencing (NGS). Association between KIR genes and COVID-19 disease severity was conducted and significant correlations were reported.
RESULTS
In the COVID-19 patients, KIR Bx genotype was more common than AA genotype. The Bx genotype was found more frequently in patients with mild disease, while in severe disease the AA genotype was more common than the Bx genotype. The KIR2DS4 gene carried the highest risk for severe COVID-19 infection (OR 8.48, pc= 0.0084) followed by KIR3DL1 (OR 7.61, pc= 0.0192).
CONCLUSIONS
Our findings suggest that KIR2DS4 and KIR3DL1 genes carry risk for severe COVID-19 disease.
背景
自然杀伤 (NK) 细胞在对抗病毒方面发挥着重要作用。NK 细胞表达杀伤细胞免疫球蛋白样受体 (KIR)，这些受体调节其活性和功能。KIR 单倍型中的多态性赋予了对由感染引起的不同病毒易感性和疾病严重程度的影响。我们研究了 KIR 基因与 COVID-19 疾病严重程度之间的关联。
方法
根据疾病严重程度将 424 例 COVID-19 阳性患者分为轻症、中症和重症三组。使用下一代测序 (NGS) 对 KIR 基因进行基因分型。对 KIR 基因与 COVID-19 疾病严重程度之间的关联进行了分析，并报告了显著相关性。
结果
在 COVID-19 患者中，KIR Bx 基因型比 AA 基因型更为常见。Bx 基因型在轻症患者中更为常见，而在重症患者中，AA 基因型比 Bx 基因型更为常见。KIR2DS4 基因对重症 COVID-19 感染的风险最高（OR 8.48，pc=0.0084），其次是 KIR3DL1（OR 7.61，pc=0.0192）。
结论
我们的研究结果表明，KIR2DS4 和 KIR3DL1 基因对重症 COVID-19 疾病具有风险。
Zotero 插件