iPSCs 和 DRGs：迈向新疼痛疗法的踏脚石。
iPSCs and DRGs: stepping stones to new pain therapies.
机构信息
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Center for Neuroscience & Regeneration Research, Yale University, West Haven, CT, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA; Yale Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Center for Neuroscience & Regeneration Research, Yale University, West Haven, CT, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, USA.
出版信息
Trends Mol Med. 2022 Feb;28(2):110-122. doi: 10.1016/j.molmed.2021.11.005. Epub 2021 Dec 18.
There is a pressing need for more effective nonaddictive treatment options for pain. Pain signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) neurons, whose excitability is driven by voltage-gated sodium (Na) channels. Three Na channels (Na1.7, Na1.8, and Na1.9), preferentially expressed in DRG neurons, play important roles in pain signaling in humans. Blockade of these channels may provide a novel approach to the treatment of pain, but clinical translation of preclinical results has been challenging, in part due to differences between rodent and human DRG neurons. Human DRG neurons and iPSC-derived sensory neurons (iPSC-SNs) provide new preclinical platforms that may facilitate the development of novel pain therapeutics.
对于疼痛，我们迫切需要更有效的非成瘾性治疗方法。疼痛信号通过背根神经节 (DRG) 神经元从外周传入脊髓，其兴奋性由电压门控钠 (Na) 通道驱动。三种 Na 通道（Na1.7、Na1.8 和 Na1.9）优先在 DRG 神经元中表达，在人类疼痛信号中发挥重要作用。阻断这些通道可能为治疗疼痛提供一种新方法，但临床转化临床前结果具有挑战性，部分原因是啮齿动物和人类 DRG 神经元之间存在差异。人类 DRG 神经元和 iPSC 衍生感觉神经元 (iPSC-SN) 提供了新的临床前平台，可能有助于新型疼痛治疗药物的开发。
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