Kamin Mukaz Debora, Gergi Mansour, Koh Insu, Zakai Neil A, Judd Suzanne E, Sholzberg Michelle, Baumann Kreuziger Lisa, Freeman Kalev, Colovos Christos, Olson Nels C, Cushman Mary
Department of Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USA.
Department of Pathology and Laboratory Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USA.
Res Pract Thromb Haemost. 2021 Dec 7;5(8):e12632. doi: 10.1002/rth2.12632. eCollection 2021 Dec.
Higher D-dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D-dimer and other thrombo-inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people.
To assess whether Black individuals have an exaggerated correlation between D-dimer and thrombo-inflammatory biomarkers characteristic of cardiovascular diseases.
Linear regression was used to assess correlations of 11 thrombo-inflammatory biomarkers with D-dimer in a cross-sectional study of 1068 participants of the biracial Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.
Adverse levels of most biomarkers, especially fibrinogen, factor VIII, C-reactive protein, N-terminal pro-B-type natriuretic peptide, and interleukin (IL)-6, were associated with higher D-dimer. Several associations with D-dimer differed significantly by race. For example, the association of factor VIII with D-dimer was more than twice as large in Black compared to White participants. Specifically, D-dimer was 26% higher per standard deviation (SD) higher factor VIII in Black adults and was only 11% higher per SD higher factor VIII in White adults. In Black but not White adults, higher IL-10 and soluble CD14 were associated with higher D-dimer.
Findings suggest that D-dimer might relate to Black/White differences in cardiovascular diseases and venous thromboembolism because it is a marker of amplified thrombo-inflammatory response in Black people. Better understanding of contributors to higher D-dimer in the general population is needed.
较高的D - 二聚体是心血管疾病和静脉血栓栓塞的一个危险因素。在一般人群中，黑人个体的D - 二聚体和其他血栓炎症生物标志物水平更高，与白人相比，他们患这些疾病的风险也更高。
评估黑人个体中D - 二聚体与心血管疾病特征性血栓炎症生物标志物之间的相关性是否更为显著。
在一项针对1068名双种族中风地理和种族差异原因（REGARDS）队列参与者的横断面研究中，采用线性回归评估11种血栓炎症生物标志物与D - 二聚体的相关性。
大多数生物标志物的不良水平，尤其是纤维蛋白原、凝血因子VIII、C反应蛋白、N末端B型利钠肽原和白细胞介素（IL）-6，与较高的D - 二聚体相关。几种与D - 二聚体的关联在种族间存在显著差异。与白人参与者相比，黑人中凝血因子VIII与D - 二聚体的关联度高出两倍多。具体而言，在黑人成年人中，凝血因子VIII每升高一个标准差（SD），D - 二聚体升高26%，而在白人成年人中，凝血因子VIII每升高一个SD，D - 二聚体仅升高11%。在黑人成年人而非白人成年人中，较高的IL - 10和可溶性CD14与较高的D - 二聚体相关。
研究结果表明，D - 二聚体可能与心血管疾病和静脉血栓栓塞中的黑人/白人差异有关，因为它是黑人血栓炎症反应增强的一个标志物。需要更好地了解一般人群中D - 二聚体升高的影响因素。
