Beijing Key Laboratory of Pharmacology of Chinese Materia Region, Xiyuan Hospital, China Academy of Chinese Medical Sciences, National Clinical Research Center for Chinese Medicine Cardiology, Beijing, 100091, China.
Chin J Integr Med. 2022 Feb;28(2):99-105. doi: 10.1007/s11655-021-3349-y. Epub 2021 Dec 20.
The abnormality of platelet function plays an important role in the pathogenesis and evolution of blood stasis syndrome (BSS). The explanation of its mechanism is a key scientific issue in the study of cardiovascular and cerebrovascular diseases and treatment. System biology technology provides a good technical platform for further development of platelet multi-omics, which is conducive to the scientific interpretation of the biological mechanism of BSS. The article summarized the pathogenesis of platelets in BSS, the mechanism of action of blood activating and stasis resolving drugs, and the application of genomics, proteomics, and metabonomics in platelet research, and put forward the concept of "plateletomics in BSS". Through the combination and cross-validation of multi-omics technology, it mainly focuses on the clinical and basic research of cardiovascular and cerebrovascular diseases; through the interactive verification of multi-omics technology and system biology, it mainly focuses on the platelet function and secretion system. The article systematically explains the molecular biological mechanism of platelet activation, aggregation, release, and other stages in the formation and development of BSS, and provides a new research idea and method for clarifying the pathogenesis of BSS and the mechanism of action of blood activating and stasis resolving drugs.
血小板功能异常在血瘀证（BSS）的发病机制和演变中起着重要作用。其机制的解释是心血管和脑血管疾病研究及治疗中的一个关键科学问题。系统生物学技术为血小板多组学的进一步发展提供了良好的技术平台，有利于科学阐释 BSS 的生物学机制。本文总结了 BSS 中血小板的发病机制、活血祛瘀药物的作用机制，以及基因组学、蛋白质组学和代谢组学在血小板研究中的应用，提出了“BSS 中的血小板组学”的概念。通过多组学技术的结合和交叉验证，主要聚焦于心血管和脑血管疾病的临床和基础研究；通过多组学技术与系统生物学的相互验证，主要聚焦于血小板功能和分泌系统。本文系统阐释了血小板在 BSS 形成和发展过程中的激活、聚集、释放等阶段的分子生物学机制，为阐明 BSS 的发病机制和活血祛瘀药物的作用机制提供了新的研究思路和方法。
