Schnor Noa Pereira Prada, Verlengia Rozangela, Novais Patrícia Fátima Sousa, Crisp Alex Harley, Leite Celso Vieira de Souza, Rasera-Junior Irineu, Oliveira Maria Rita Marques de
Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp), Programa de Pós-Graduação em Alimentos e Nutrição, Araraquara, SP, Brasil.
Universidade Metodista de Piracicaba (Unimep), Programa de Pós-Graduação em Ciências do Movimento Humano, Piracicaba, SP, Brasil.
Arch Endocrinol Metab. 2017 Jul-Aug;61(4):326-331. doi: 10.1590/2359-3997000000260.
Obesity can cause systemic arterial hypertension (SAH) and type 2 diabetes mellitus (DM2) factor that is also influenced by genetic variability. The present study aims to investigate the association between gene polymorphisms related with obesity on the prevalence of SAH and DM2 in the preoperative period and 1 year after Roux-en-Y gastric bypass surgery.
In total, 351 obese women in a Brazilian cohort completed the study. The clinical diagnosis of SAH and DM2 was monitored from medical records. Twelve gene polymorphisms (rs26802; rs572169; rs7799039; rs1137101; rs3813929; rs659366; rs660339; rs1800849; rs7498665; rs35874116; rs9701796; and rs9939609) were determined using real-time polymerase chain reaction and TaqMan assay.
In the preoperative period, prevalence of SAH and DM2 was 57% and 22%, respectively. One year postoperatively, 86.8% subjects had remission of DM2 and 99.5% had control of SAH. Subjects with T allele from the serotonin receptor gene (5-HT2C, rs3813929) had five times greater chance of DM2, and the CC genotype from uncoupling protein 3 gene (UCP3, rs1800849) had three times greater chance in the preoperative period.
These findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 genes were related to DM2 prevalence among the Brazilian obese women candidates for bariatric surgery.
肥胖可导致系统性动脉高血压（SAH）和2型糖尿病（DM2），而这一因素也受基因变异性的影响。本研究旨在调查肥胖相关基因多态性与Roux-en-Y胃旁路手术术前及术后1年SAH和DM2患病率之间的关联。
巴西队列中的351名肥胖女性完成了本研究。通过病历监测SAH和DM2的临床诊断。使用实时聚合酶链反应和TaqMan分析法测定12种基因多态性（rs26802；rs572169；rs7799039；rs1137101；rs3813929；rs659366；rs660339；rs1800849；rs7498665；rs35874116；rs9701796；以及rs9939609）。
术前，SAH和DM2的患病率分别为57%和22%。术后1年，86.8%的受试者DM2得到缓解，99.5%的受试者SAH得到控制。血清素受体基因（5-HT2C，rs3813929）携带T等位基因的受试者患DM2的几率高出五倍，解偶联蛋白3基因（UCP3，rs1800849）的CC基因型受试者在术前患DM2的几率高出三倍。
这些发现表明，5-HT2C和UCP3基因的多态性rs3813929和rs1800849与巴西肥胖女性减肥手术候选者的DM2患病率相关。
