School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Shenyang Xingqi Pharmaceutical Co., Ltd, Shenyang, People's Republic of China.
Nat Prod Res. 2022 Nov;36(21):5429-5437. doi: 10.1080/14786419.2021.2013215. Epub 2021 Dec 22.
Four sesquiterpenoids A-D (-) were isolated from the ethanol extracts of the leaves and stems from . Their structures and absolute configurations were elucidated by a combination of NMR, MS and ECD. Compounds - (10 μM) exhibited moderate hepatoprotective activities against APAP-induced LO2 cell damage with increasing cell viability by 18%, 17%, 16%, and 19% compared to the model group (bicyclol, 26%) at 10 μM, respectively. All the compounds displayed no cytotoxic activity against five human cell lines, which also suggested the safety of leaves and stems of as an edible vegetable in a degree.
从 的叶茎乙醇提取物中分离得到四个倍半萜 A-D(-)。通过 NMR、MS 和 ECD 的组合，阐明了它们的结构和绝对构型。化合物 - (10 μM) 对 APAP 诱导的 LO2 细胞损伤具有中等的肝保护活性，与模型组相比，细胞活力分别提高了 18%、17%、16%和 19%（双环醇，26%）在 10 μM 时。所有化合物对五种人细胞系均无细胞毒性，这也表明 的叶茎在一定程度上作为食用蔬菜是安全的。
