School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China.
J Asian Nat Prod Res. 2022 Jan;24(1):76-87. doi: 10.1080/10286020.2021.2016715. Epub 2021 Dec 23.
Renal fibrosis is a critical pathological process lead to a progressive loss of renal function. Jolkinolide B (JB) is a natural compound with anti-inflammatory activity from Steud. The study evaluated the effect of JB on renal fibrosis in mice with unilateral ureteral obstruction (UUO). The results showed that JB could decrease renal fibrotic area, reduce phosphorylation of NF-κB p65 and the release of TNF-α, IL-6 and IL-1β, restore the expression of vementin, α-SMA and E-cadherin, as well as TGF-β1 and p-smad2/3. In conclusion, JB might reduce renal fibrosis by inhibiting inflammation induced by NF-κB pathway and EMT mediated by TGF-β1/Smad pathway.
肾纤维化是导致肾功能进行性丧失的关键病理过程。冬凌草甲素（JB）是一种具有抗炎活性的天然化合物，来自 Steud。本研究评估了 JB 对单侧输尿管梗阻（UUO）小鼠肾纤维化的影响。结果表明，JB 可减少肾纤维化面积，降低 NF-κB p65 的磷酸化和 TNF-α、IL-6 和 IL-1β的释放，恢复波形蛋白、α-SMA 和 E-cadherin 的表达，以及 TGF-β1 和 p-smad2/3。总之，JB 可能通过抑制 NF-κB 通路诱导的炎症和 TGF-β1/Smad 通路介导的 EMT 来减少肾纤维化。
