文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

牛津-阿斯利康 COVID-19 疫苗的研发资金来自哪里?

Who funded the research behind the Oxford-AstraZeneca COVID-19 vaccine?

机构信息

Faculty of Medicine, Imperial College London, London, UK.

NHS Highland, Inverness, UK.

出版信息

BMJ Glob Health. 2021 Dec;6(12). doi: 10.1136/bmjgh-2021-007321.


DOI:10.1136/bmjgh-2021-007321
PMID:34937701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8704023/
Abstract

OBJECTIVES: The Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19, Vaxzevira or Covishield) builds on two decades of research and development (R&D) into chimpanzee adenovirus-vectored vaccine (ChAdOx) technology at the University of Oxford. This study aimed to approximate the funding for the R&D of ChAdOx and the Oxford-AstraZeneca vaccine and to assess the transparency of funding reporting mechanisms. METHODS: We conducted a scoping review and publication history analysis of the principal investigators to reconstruct R&D funding the ChAdOx technology. We matched award numbers with publicly accessible grant databases. We filed freedom of information (FOI) requests to the University of Oxford for the disclosure of all grants for ChAdOx R&D. RESULTS: We identified 100 peer-reviewed articles relevant to ChAdOx technology published between January 2002 and October 2020, extracting 577 mentions of funding bodies from acknowledgements. Government funders from overseas (including the European Union) were mentioned 158 times (27.4%), the UK government 147 (25.5%) and charitable funders 138 (23.9%). Grant award numbers were identified for 215 (37.3%) mentions; amounts were publicly available for 121 (21.0%). Based on the FOIs, until December 2019, the biggest funders of ChAdOx R&D were the European Commission (34.0%), Wellcome Trust (20.4%) and Coalition for Epidemic Preparedness Innovations (17.5%). Since January 2020, the UK government contributed 95.5% of funding identified. The total identified R&D funding was £104 226 076 reported in the FOIs and £228 466 771 reconstructed from the literature search. CONCLUSION: Our study approximates that public and charitable financing accounted for 97%-99% of identifiable funding for the ChAdOx vaccine technology research at the University of Oxford underlying the Oxford-AstraZeneca vaccine until autumn 2020. We encountered a lack of transparency in research funding reporting.

摘要

目的:牛津-阿斯利康 COVID-19 疫苗(ChAdOx1 nCoV-19,Vaxzevira 或 Covishield)建立在牛津大学对 chimpanzee adenovirus-vectored vaccine(ChAdOx)技术长达二十年的研究和开发(R&D)之上。本研究旨在估算 ChAdOx 和牛津-阿斯利康疫苗的 R&D 资金,并评估资金报告机制的透明度。

方法:我们对主要研究人员进行了范围界定审查和出版物历史分析,以重建 ChAdOx 技术的 R&D 资金。我们将奖励编号与可公开访问的赠款数据库进行匹配。我们向牛津大学提出了信息自由(FOI)请求,要求披露所有 ChAdOx R&D 的赠款。

结果:我们确定了 100 篇与 ChAdOx 技术相关的同行评议文章,这些文章发表于 2002 年 1 月至 2020 年 10 月之间,从致谢中提取了 577 次资金来源的提及。来自海外(包括欧盟)的政府资助者被提及 158 次(27.4%),英国政府 147 次(25.5%),慈善资助者 138 次(23.9%)。确定了 215 次(37.3%)提及的赠款奖励编号;可公开获取 121 次(21.0%)的金额。根据 FOI,截至 2019 年 12 月,ChAdOx R&D 的最大资助者是欧盟委员会(34.0%)、惠康信托基金(20.4%)和流行病防范创新联盟(17.5%)。自 2020 年 1 月以来,英国政府贡献了 95.5%的已确定资金。FOI 中报告的总 R&D 资金为 104226076 英镑,从文献检索中重建的资金为 228466771 英镑。

结论:我们的研究表明,在 2020 年秋季之前,公共和慈善资金为牛津大学 ChAdOx 疫苗技术研究提供了 97%-99%的可识别资金,为牛津-阿斯利康疫苗奠定了基础。我们发现研究资金报告缺乏透明度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/c6f8fd611e0f/bmjgh-2021-007321f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/223d8cb8204c/bmjgh-2021-007321f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/9370cc66af5e/bmjgh-2021-007321f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/996fad08e55c/bmjgh-2021-007321f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/c30334de259b/bmjgh-2021-007321f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/c6f8fd611e0f/bmjgh-2021-007321f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/223d8cb8204c/bmjgh-2021-007321f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/9370cc66af5e/bmjgh-2021-007321f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/996fad08e55c/bmjgh-2021-007321f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/c30334de259b/bmjgh-2021-007321f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e54/8704023/c6f8fd611e0f/bmjgh-2021-007321f05.jpg

相似文献

[1]
Who funded the research behind the Oxford-AstraZeneca COVID-19 vaccine?

BMJ Glob Health. 2021-12

[2]
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.

Lancet. 2020-11-19

[3]
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.

Lancet. 2021-3-6

[4]
An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females.

EBioMedicine. 2022-7

[5]
Sustained COVID-19 vaccine willingness after safety concerns over the Oxford-AstraZeneca vaccine.

Dan Med J. 2021-3-31

[6]
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial.

Lancet. 2021-4-10

[7]
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

Lancet. 2021-1-9

[8]
Efficacy of Oxford-AstraZeneca (ChAdOx1 CoV-19) vaccine against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) cases, hospital admissions, type of variants, and deaths.

Eur Rev Med Pharmacol Sci. 2023-10

[9]
Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial.

EBioMedicine. 2022-11

[10]
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial.

Lancet HIV. 2021-8

引用本文的文献

[1]
Contrasting academic approaches to COVID-19 vaccine production and distribution: What can the Oxford and Texas experiences teach us about pandemic response?

Health Aff Sch. 2024-1-31

[2]
COVID-19 vaccine apartheid and the failure of global cooperation.

Br J Polit Int Relat. 2023-8

[3]
Which roads lead to access? A global landscape of six COVID-19 vaccine innovation models.

Global Health. 2024-3-26

[4]
A Pathway to Health for All.

J Law Med Ethics. 2023

[5]
Unveiling patenting strategies of therapeutics and vaccines: evergreening in the context of COVID-19 pandemic.

Front Med (Lausanne). 2023-12-6

[6]
Special FDA designations for drug development: orphan, fast track, accelerated approval, priority review, and breakthrough therapy.

Eur J Health Econ. 2024-8

[7]
Biopharmaceutical Financialization and Public Funding of Medical Countermeasures (MCMs) in Canada During the COVID-19 Pandemic.

Int J Health Policy Manag. 2023

[8]
Scarcity, Property Rights, Irresponsibility: How Intellectual Property Deals with Neglected Tropical Diseases.

Law Crit. 2023

[9]
Discrepancies among Scopus and Web of Science, coverage of funding information in medical journal articles: a follow-up study.

J Med Libr Assoc. 2023-7-10

[10]
Serological Evaluation of Antibody Titers After Vaccination Against COVID-19 in 18-44-Year-Old Individuals at a Tertiary Care Center.

Cureus. 2023-6-16

本文引用的文献

[1]
University patenting and licensing practices in the United Kingdom during the first year of the COVID-19 pandemic.

Glob Public Health. 2022-5

[2]
Structural violence and the biomedical innovation system: what responsibility do universities have in ensuring access to health technologies?

BMJ Glob Health. 2021-5

[3]
NIH funding for vaccine readiness before the COVID-19 pandemic.

Vaccine. 2021-4-22

[4]
What scientists do and don't know about the Oxford-AstraZeneca COVID vaccine.

Nature. 2021-4

[5]
Making a COVID-19 vaccine that works for everyone: ensuring equity and inclusivity in clinical trials.

Glob Health Action. 2021-1-1

[6]
The coronavirus is here to stay - here's what that means.

Nature. 2021-2

[7]
Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment.

Lancet. 2021-3-13

[8]
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.

Lancet. 2020-11-19

[9]
Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity.

Int J Health Policy Manag. 2022-5-1

[10]
The unequal scramble for coronavirus vaccines - by the numbers.

Nature. 2020-8

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索