Faculty of Medicine, Imperial College London, London, UK.
NHS Highland, Inverness, UK.
BMJ Glob Health. 2021 Dec;6(12). doi: 10.1136/bmjgh-2021-007321.
OBJECTIVES: The Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19, Vaxzevira or Covishield) builds on two decades of research and development (R&D) into chimpanzee adenovirus-vectored vaccine (ChAdOx) technology at the University of Oxford. This study aimed to approximate the funding for the R&D of ChAdOx and the Oxford-AstraZeneca vaccine and to assess the transparency of funding reporting mechanisms. METHODS: We conducted a scoping review and publication history analysis of the principal investigators to reconstruct R&D funding the ChAdOx technology. We matched award numbers with publicly accessible grant databases. We filed freedom of information (FOI) requests to the University of Oxford for the disclosure of all grants for ChAdOx R&D. RESULTS: We identified 100 peer-reviewed articles relevant to ChAdOx technology published between January 2002 and October 2020, extracting 577 mentions of funding bodies from acknowledgements. Government funders from overseas (including the European Union) were mentioned 158 times (27.4%), the UK government 147 (25.5%) and charitable funders 138 (23.9%). Grant award numbers were identified for 215 (37.3%) mentions; amounts were publicly available for 121 (21.0%). Based on the FOIs, until December 2019, the biggest funders of ChAdOx R&D were the European Commission (34.0%), Wellcome Trust (20.4%) and Coalition for Epidemic Preparedness Innovations (17.5%). Since January 2020, the UK government contributed 95.5% of funding identified. The total identified R&D funding was £104 226 076 reported in the FOIs and £228 466 771 reconstructed from the literature search. CONCLUSION: Our study approximates that public and charitable financing accounted for 97%-99% of identifiable funding for the ChAdOx vaccine technology research at the University of Oxford underlying the Oxford-AstraZeneca vaccine until autumn 2020. We encountered a lack of transparency in research funding reporting.
目的:牛津-阿斯利康 COVID-19 疫苗(ChAdOx1 nCoV-19,Vaxzevira 或 Covishield)建立在牛津大学对 chimpanzee adenovirus-vectored vaccine(ChAdOx)技术长达二十年的研究和开发(R&D)之上。本研究旨在估算 ChAdOx 和牛津-阿斯利康疫苗的 R&D 资金,并评估资金报告机制的透明度。
方法:我们对主要研究人员进行了范围界定审查和出版物历史分析,以重建 ChAdOx 技术的 R&D 资金。我们将奖励编号与可公开访问的赠款数据库进行匹配。我们向牛津大学提出了信息自由(FOI)请求,要求披露所有 ChAdOx R&D 的赠款。
结果:我们确定了 100 篇与 ChAdOx 技术相关的同行评议文章,这些文章发表于 2002 年 1 月至 2020 年 10 月之间,从致谢中提取了 577 次资金来源的提及。来自海外(包括欧盟)的政府资助者被提及 158 次(27.4%),英国政府 147 次(25.5%),慈善资助者 138 次(23.9%)。确定了 215 次(37.3%)提及的赠款奖励编号;可公开获取 121 次(21.0%)的金额。根据 FOI,截至 2019 年 12 月,ChAdOx R&D 的最大资助者是欧盟委员会(34.0%)、惠康信托基金(20.4%)和流行病防范创新联盟(17.5%)。自 2020 年 1 月以来,英国政府贡献了 95.5%的已确定资金。FOI 中报告的总 R&D 资金为 104226076 英镑,从文献检索中重建的资金为 228466771 英镑。
结论:我们的研究表明,在 2020 年秋季之前,公共和慈善资金为牛津大学 ChAdOx 疫苗技术研究提供了 97%-99%的可识别资金,为牛津-阿斯利康疫苗奠定了基础。我们发现研究资金报告缺乏透明度。
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