Matheson D S, Green B J
J Immunol. 1987 Apr 15;138(8):2469-72.
The case history of a boy who presented at 6 mo of age with pneumocystis carinii pneumonia is described. Hypogammaglobulinemia was detected. His T lymphocytes and B lymphocytes proliferated with mitogens but no immunoglobulin was secreted secondary to polyclonal stimulation with pokeweed mitogen. His peripheral blood mononuclear cells secreted interleukin 2 and B cell growth factor (BCGF) but failed to secrete detectable levels of B cell differentiation factor (BCDF). Studies of his B lymphocytes showed that they would secrete immunoglobulin in vitro after exposure to a supernatant containing BCDF activity. Hence regulatory control of these lymphokines appears to be independent, and this case illustrates the pathologic sequellae of a defect in BCDF-like production.
本文描述了一名6个月大时出现卡氏肺囊虫肺炎男孩的病史。检测到低丙种球蛋白血症。他的T淋巴细胞和B淋巴细胞对有丝分裂原发生增殖，但在用商陆有丝分裂原进行多克隆刺激后未分泌免疫球蛋白。他的外周血单个核细胞分泌白细胞介素2和B细胞生长因子（BCGF），但未能分泌可检测水平的B细胞分化因子（BCDF）。对他的B淋巴细胞研究表明，在暴露于含有BCDF活性的上清液后，它们会在体外分泌免疫球蛋白。因此，这些淋巴因子的调节控制似乎是独立的，该病例说明了类似BCDF产生缺陷的病理后果。
