NRF2在分枝杆菌感染中的作用。
The Role of NRF2 in Mycobacterial Infection.
作者信息
Matsuyama Masashi, Nonaka Mizu, Nakajima Masayuki, Morishima Yuko, Ishii Yukio, Hizawa Nobuyuki
机构信息
Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan.
出版信息
Antioxidants (Basel). 2021 Nov 23;10(12):1861. doi: 10.3390/antiox10121861.
The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of and infection.
全球范围内，肺部非结核分枝杆菌（NTM）感染的发病率正在上升，而目前化疗的临床效果并不理想。非洲的结核病（TB）发病率仍然很高，耐多药结核病的存在也是治疗中的一个重要问题。为了发现和开发新的有效抗分枝杆菌治疗方法，了解宿主针对分枝杆菌感染的防御机制非常重要。核红细胞2 p45相关因子2（NRF2）是各种抗氧化反应元件（ARE）驱动的细胞保护基因表达的主要调节因子，其保护作用已在感染中得到证实。然而，关于NRF2在分枝杆菌感染性疾病中的作用的论文或综述并不多。因此，本综述重点关注NRF2在[具体疾病名称1]和[具体疾病名称2]感染发病机制中的作用。 （注：原文中“ and ”处应补充具体疾病名称，译文此处保留原文格式以便你根据实际情况补充完整）
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