Yamaguchi Toshihiro, Kitahara Shuji, Kusuda Kaori, Okamoto Jun, Horise Yuki, Masamune Ken, Muragaki Yoshihiro
Faculty of Advanced Techno Surgery (FATS), Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku, Tokyo 162-8666, Japan.
Cancers (Basel). 2021 Dec 8;13(24):6184. doi: 10.3390/cancers13246184.
Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer and focused ultrasound. A high-intensity focused ultrasound (HIFU) beam is used to destroy or denature targeted cancer tissues. Some SDTs are based on unfocused ultrasound (US). In some SDTs, HIFU is combined with a drug, known as a chemical sonosensitizer, to amplify the drug's ability to damage cancer cells preferentially. The mechanism by which US interferes with cancer cell function is further amplified by applying acoustic sensitizers. Combining multiple chemical sonosensitizers with US creates a substantial synergistic effect that could effectively disrupt tumorigenic growth, induce cell death, and elicit an immune response. Therefore, the minimally invasive SDT treatment is currently attracting attention. It can be combined with targeted therapy (double-targeting cancer therapy) and immunotherapy in the future and is expected to be a boon for treating previously incurable cancers. In this paper, we will consider the current state of this therapy and discuss parts of our research.
近期的进展切实改变了癌症治疗的格局。然而，针对这种可怕疾病的根治性疗法仍是一项未被满足的需求。声动力疗法（SDT）是一种微创抗癌疗法，涉及化学声敏剂和聚焦超声。高强度聚焦超声（HIFU）束用于破坏或使靶向癌细胞组织变性。一些声动力疗法基于非聚焦超声（US）。在某些声动力疗法中，HIFU与一种称为化学声敏剂的药物相结合，以增强该药物优先损伤癌细胞的能力。通过应用声敏剂，超声干扰癌细胞功能的机制进一步增强。将多种化学声敏剂与超声相结合可产生显著的协同效应，有效破坏肿瘤生长、诱导细胞死亡并引发免疫反应。因此，微创声动力疗法目前正受到关注。它未来可与靶向疗法（双靶点癌症治疗）和免疫疗法相结合，有望成为治疗以往无法治愈癌症的福音。在本文中，我们将探讨这种疗法的现状并讨论我们研究的部分内容。
