Christiansen Pia, Pedersen Caroline Hornnes, Selter Hansjörg, Odder Lillian, Riisager Jette Præstholm, Damgaard Kjeld, Westmark Signe, Bruun Niels Henrik, Melgaard Dorte
Clinic of Anaesthesia, Aalborg University Hospital, 7700 Thisted, Denmark.
Clinic of Anaesthesia, North Denmark Regional Hospital, 9800 Hjoerring, Denmark.
J Clin Med. 2021 Dec 13;10(24):5846. doi: 10.3390/jcm10245846.
Sore throat (POST) and hoarseness (PH) are common complaints after endotracheal intubation (EI). The aim of this study was to investigate whether tube size impacts the experiences of POST and PH after EI in patients undergoing elective surgery, as well as to document a possible role of gender. This randomised, controlled, blinded study was conducted at Aalborg University Hospital, Thisted, Denmark or North Denmark Regional Hospital, Denmark. A total of 236 patients (53.4% female, mean age 50.9 years (SD 14.0)) were enrolled from the departments of gynaecology, parenchyma and orthopaedics. The patients were randomised to a tube size of 8.0 or 7.0 for males and 7.0 or 6.0 for females. Tube sizes were known to the anaesthesia staff but blinded for patients, researchers and staff at the postoperative care unit. POST and/or PH was reported 30-60 min before anaesthesia, at 30 min and at 2, 5, 12, 24, 48, 72 and 96 h after anaesthesia. Both female and male patients experienced significantly lower levels of POST and PH after intubation with the smallest tube size. This study demonstrates that a smaller size of tube results in a reduction in POST and PH after EI for both male and female patients.
喉咙痛（POST）和声音嘶哑（PH）是气管插管（EI）后常见的主诉。本研究的目的是调查导管尺寸是否会影响择期手术患者EI后POST和PH的体验，并记录性别的可能作用。这项随机、对照、双盲研究在丹麦蒂斯特的奥尔堡大学医院或丹麦北丹麦地区医院进行。共有236名患者（53.4%为女性，平均年龄50.9岁（标准差14.0））从妇科、实质器官科和骨科招募。男性患者随机分为使用8.0或7.0尺寸的导管，女性患者随机分为使用7.0或6.0尺寸的导管。麻醉人员知道导管尺寸，但患者、研究人员和术后护理单元的工作人员对此不知情。在麻醉前30 - 60分钟、麻醉后30分钟以及2、5、12、24、48、72和96小时报告POST和/或PH情况。无论男性还是女性患者，使用最小尺寸的导管插管后POST和PH的水平均显著降低。本研究表明，较小尺寸的导管可降低男性和女性患者EI后POST和PH的发生率。
