用于生物医学应用的商用印刷电路板的生物相容性研究：用于视网膜组织培养的印刷电路板实验室。

Biocompatibility Study of a Commercial Printed Circuit Board for Biomedical Applications: Lab-on-PCB for Organotypic Retina Cultures.

作者信息

Urbano-Gámez Jesús David, Valdés-Sánchez Lourdes, Aracil Carmen, de la Cerda Berta, Perdigones Francisco, Plaza Reyes Álvaro, Díaz-Corrales Francisco J, Relimpio López Isabel, Quero José Manuel

机构信息

Electronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain.

Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain.

出版信息

Micromachines (Basel). 2021 Nov 29;12(12):1469. doi: 10.3390/mi12121469.

DOI:10.3390/mi12121469

PMID:34945319

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8707730/

Abstract

Printed circuit board (PCB) technology is well known, reliable, and low-cost, and its application to biomedicine, which implies the integration of microfluidics and electronics, has led to Lab-on-PCB. However, the biocompatibility of the involved materials has to be examined if they are in contact with biological elements. In this paper, the solder mask (PSR-2000 CD02G/CA-25 CD01, Taiyo Ink (Suzhou) Co., Ltd., Suzhou, China) of a commercial PCB has been studied for retinal cultures. For this purpose, retinal explants have been cultured over this substrate, both on open and closed systems, with successful results. Cell viability data shows that the solder mask has no cytotoxic effect on the culture allowing the application of PCB as the substrate of customized microelectrode arrays (MEAs). Finally, a comparative study of the biocompatibility of the 3D printer Uniz zSG amber resin has also been carried out.

摘要

印刷电路板（PCB）技术广为人知、可靠且成本低廉，其在生物医学中的应用，即将微流体技术与电子技术相结合，催生了基于印刷电路板的实验室（Lab-on-PCB）。然而，如果所涉及的材料与生物元件接触，就必须检查其生物相容性。在本文中，对一种商用印刷电路板的阻焊层（PSR-2000 CD02G/CA-25 CD01，太阳油墨（苏州）有限公司，中国苏州）进行了视网膜培养研究。为此，在开放和封闭系统中，均已在该基板上培养了视网膜外植体，并取得了成功结果。细胞活力数据表明，阻焊层对培养物没有细胞毒性作用，这使得印刷电路板能够用作定制微电极阵列（MEA）的基板。最后，还对3D打印机Uniz zSG琥珀树脂的生物相容性进行了比较研究。