Perdigones Francisco, Quero José Manuel
Electronic Engineering Department, University of Seville, 41092 Sevilla, Spain.
Micromachines (Basel). 2022 Mar 17;13(3):460. doi: 10.3390/mi13030460.
This paper describes the fabrication opportunities that Printed Circuit Boards (PCBs) offer for electronic and biomedical engineering. Historically, PCB substrates have been used to support the components of the electronic devices, linking them using copper lines, and providing input and output pads to connect the rest of the system. In addition, this kind of substrate is an emerging material for biomedical engineering thanks to its many interesting characteristics, such as its commercial availability at a low cost with very good tolerance and versatility, due to its multilayer characteristics; that is, the possibility of using several metals and substrate layers. The alternative uses of copper, gold, Flame Retardant 4 (FR4) and silver layers, together with the use of vias, solder masks and a rigid and flexible substrate, are noted. Among other uses, these characteristics have been using to develop many sensors, biosensors and actuators, and PCB-based lab-on chips; for example, deoxyribonucleic acid (DNA) amplification devices for Polymerase Chain Reaction (PCR). In addition, several applications of these devices are going to be noted in this paper, and two tables summarizing the layers' functions are included in the discussion: the first one for metallic layers, and the second one for the vias, solder mask, flexible and rigid substrate functions.
本文介绍了印刷电路板（PCB）为电子和生物医学工程提供的制造机会。从历史上看，PCB基板一直用于支撑电子设备的组件，用铜线将它们连接起来，并提供输入和输出焊盘以连接系统的其余部分。此外，由于其许多有趣的特性，这种基板成为生物医学工程领域的一种新兴材料，例如其具有商业可用性，成本低，耐受性和通用性非常好，这得益于其多层特性；也就是说，可以使用多种金属和基板层。文中提到了铜、金、阻燃剂4（FR4）和银层的替代用途，以及过孔、阻焊层和刚性与柔性基板的使用。除其他用途外，这些特性已被用于开发许多传感器、生物传感器和致动器以及基于PCB的芯片实验室；例如，用于聚合酶链反应（PCR）的脱氧核糖核酸（DNA）扩增装置。此外，本文还将介绍这些装置的一些应用，并在讨论中包含两个总结各层功能的表格：第一个是金属层的，第二个是过孔、阻焊层、柔性和刚性基板功能的。
