Institute for Biochemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Zuelpicher Str. 47a, 50674 Cologne, Germany.
Int J Mol Sci. 2021 Dec 8;22(24):13212. doi: 10.3390/ijms222413212.
Biofilm formation and inflammations are number one reasons of implant failure and cause a severe number of postoperative complications every year. To functionalize implant surfaces with antibiotic agents provides perspectives to minimize and/or prevent bacterial adhesion and proliferation. In recent years, antimicrobial peptides (AMP) have been evolved as promising alternatives to commonly used antibiotics, and have been seen as potent candidates for antimicrobial surface coatings. This review aims to summarize recent developments in this field and to highlight examples of the most common techniques used for preparing such AMP-based medical devices. We will report on three different ways to pursue peptide coatings, using either binding sequences (primary approach), linker layers (secondary approach), or loading in matrixes which offer a defined release (tertiary approach). All of them will be discussed in the light of current research in this area.
生物膜的形成和炎症是导致植入物失效的首要原因，每年都会引发大量术后并发症。用抗生素对植入物表面进行功能化处理为减少和/或预防细菌黏附和增殖提供了新的思路。近年来，抗菌肽（antimicrobial peptides，AMP）已被开发为常用抗生素的替代品，被视为抗菌表面涂层的有力候选物。本综述旨在总结该领域的最新进展，并突出展示用于制备此类基于 AMP 的医疗器械的最常见技术的示例。我们将报告三种不同的方法来进行肽涂层处理，即使用结合序列（主要方法）、连接层（次要方法）或在提供受控释放的基质中进行负载（三级方法）。所有这些方法都将结合该领域的当前研究进行讨论。
