State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
School of Chemical Engineering and Technology, Xinjiang University, Urumqi 830046, China.
Int J Mol Sci. 2021 Dec 16;22(24):13516. doi: 10.3390/ijms222413516.
Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented.
水凝胶具有多孔结构，广泛应用于材料和生物医药领域。作为一种天然低聚糖，环糊精（CD）在水凝胶的合成和利用方面显示出了显著的应用前景。CD 可以掺入水凝胶中，形成化学或物理交联网络。此外，CD 的独特空腔结构使其成为将活性成分递送到靶组织的理想载体。本文综述了制备含 CD 的水凝胶的有用方法。此外，还综述了含 CD 的水凝胶在生物医学中的潜在应用。讨论了在不同条件下含 CD 的水凝胶的释放和降解过程。最后，提出了含 CD 的水凝胶目前面临的挑战和未来的研究方向。
