Cardiovascular Diseases and Diabetes Biology Division, Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud Post, Poojappura, Trivandrum 695014, Kerala, India.
Biomed Pharmacother. 2022 Feb;146:112560. doi: 10.1016/j.biopha.2021.112560. Epub 2021 Dec 22.
Quercetin, a bioflavonoid abundant in grapefruit, onion, berries, etc., has vast therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin showed similar effects as that of metformin, (widely prescribed antidiabetic drug) in cell lines models (Sajan et al., 2010; Dhanya et al., 2017). In vivo findings also showcase it as a promising agent against diabetes and its pathophysiological complications.
Quercetin can be produced on a large scale through a novel fermentation-based glycosylation strategy from cheap substrates and can be utilized as a dietary supplement. The review focuses on the mounting evidence pointing to Quercetin as a promising candidate for managing type 2 diabetes and its oxidative stress mediated pathophysiological complications.
Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.
槲皮素是一种在葡萄柚、洋葱、浆果等中含量丰富的生物类黄酮，具有广泛的治疗潜力，特别是针对 2 型糖尿病及其并发症。槲皮素在细胞系模型中表现出与二甲双胍（广泛开的抗糖尿病药物）相似的效果（Sajan 等人，2010 年；Dhanya 等人，2017 年）。体内研究结果也表明它是一种对抗糖尿病及其病理生理并发症的有前途的药物。
槲皮素可以通过一种新颖的基于发酵的糖基化策略，从廉价的底物大量生产，并可用作膳食补充剂。本综述重点介绍了越来越多的证据表明槲皮素是治疗 2 型糖尿病及其氧化应激介导的病理生理并发症的有前途的候选药物。
槲皮素作用于糖尿病的多个靶点，并调节关键信号通路，从而改善 2 型糖尿病的症状和并发症。然而，仍需要进一步的研究来提高生物利用度，并为槲皮素建立剂量方案。
