School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Food Chem. 2022 May 1;375:131896. doi: 10.1016/j.foodchem.2021.131896. Epub 2021 Dec 20.
Hericium erinaceus, a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. However, the relationship between the structural characteristics of Hericium erinaceus and its stomach-protecting activity remains unclear. Here, the structural properties of two polysaccharides from Hericium erinaceus, mycelium polysaccharide (HMP) and fruiting body polysaccharide (HFP) were investigated by spectral approaches. The results showed that the distribution of HMP was more uniform compared to HFP. Both HMP and HFP have triple helix structures, but the HMP conformation showed greater stability. Subsequently, the preventive effect of HMP and HFP on ethanol-induced gastric mucosal injury was also evaluated in rats and GES-1 cells, and it showed that both HMP and HFP had significant protective activity against gastric mucosal injury, but HMP showed better activity than HFP. These results suggested that conformational stability polysaccharide in Hericium erinaceus is more related to its gastric-protecting activity.
猴头菇，一种传统的食用蘑菇，被称为药食同源，可改善胃肠道疾病。然而，猴头菇的结构特征与其胃保护活性之间的关系尚不清楚。在这里，通过光谱方法研究了猴头菇的两种多糖，菌丝体多糖（HMP）和子实体多糖（HFP）的结构特性。结果表明，HMP 的分布比 HFP 更均匀。HMP 和 HFP 均具有三螺旋结构，但 HMP 构象表现出更高的稳定性。随后，还在大鼠和 GES-1 细胞中评估了 HMP 和 HFP 对乙醇诱导的胃黏膜损伤的预防作用，结果表明，HMP 和 HFP 均对胃黏膜损伤具有显著的保护作用，但 HMP 的活性优于 HFP。这些结果表明，猴头菇中构象稳定的多糖与其胃保护活性更为相关。
