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银纳米颗粒作为潜在的抗病毒剂。

Silver Nanoparticles as Potential Antiviral Agents.

作者信息

Ratan Zubair Ahmed, Mashrur Fazla Rabbi, Chhoan Anisha Parsub, Shahriar Sadi Md, Haidere Mohammad Faisal, Runa Nusrat Jahan, Kim Sunggyu, Kweon Dae-Hyuk, Hosseinzadeh Hassan, Cho Jae Youl

机构信息

Department of Biomedical Engineering, Khulna University of Engineering & Technology, Khulna 9203, Bangladesh.

School of Health and Society, University of Wollongong, Wollongong, NSW 2500, Australia.

出版信息

Pharmaceutics. 2021 Nov 29;13(12):2034. doi: 10.3390/pharmaceutics13122034.

Abstract

Since the early 1990s, nanotechnology has led to new horizons in nanomedicine, which encompasses all spheres of science including chemistry, material science, biology, and biotechnology. Emerging viral infections are creating severe hazards to public health worldwide, recently, COVID-19 has caused mass human casualties with significant economic impacts. Interestingly, silver nanoparticles (AgNPs) exhibited the potential to destroy viruses, bacteria, and fungi using various methods. However, developing safe and effective antiviral drugs is challenging, as viruses use host cells for replication. Designing drugs that do not harm host cells while targeting viruses is complicated. In recent years, the impact of AgNPs on viruses has been evaluated. Here, we discuss the potential role of silver nanoparticles as antiviral agents. In this review, we focus on the properties of AgNPs such as their characterization methods, antiviral activity, mechanisms, applications, and toxicity.

摘要

自20世纪90年代初以来,纳米技术为纳米医学带来了新的视野,纳米医学涵盖了包括化学、材料科学、生物学和生物技术在内的所有科学领域。新出现的病毒感染正在给全球公共卫生造成严重危害,最近,新冠病毒已导致大量人员伤亡,并产生了重大经济影响。有趣的是,银纳米颗粒(AgNPs)显示出利用各种方法破坏病毒、细菌和真菌的潜力。然而,开发安全有效的抗病毒药物具有挑战性,因为病毒利用宿主细胞进行复制。设计在靶向病毒的同时不伤害宿主细胞的药物很复杂。近年来,人们评估了银纳米颗粒对病毒的影响。在此,我们讨论银纳米颗粒作为抗病毒剂的潜在作用。在这篇综述中,我们重点关注银纳米颗粒的特性,如它们的表征方法、抗病毒活性、作用机制、应用和毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda3/8705988/4e68f35b0391/pharmaceutics-13-02034-g001.jpg

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