Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Eur J Nutr. 2022 Sep;61(6):3247-3254. doi: 10.1007/s00394-022-02880-5. Epub 2022 Apr 22.
Whole-grain intake assessed through self-reported methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in epidemiological studies. However, few studies have evaluated the association between whole-grain intake and MetS risk using objective biomarkers of whole-grain intake. The aim of this study was to examine the association between plasma 3-(3,5-Dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, and MetS risk in a Chinese population.
A case-control study of 667 MetS cases and 667 matched controls was conducted based on baseline data of the Tongji-Ezhou Cohort study. Plasma DHPPA concentrations were assessed by high-performance liquid chromatography-tandem mass spectrometry. The MetS was defined based on criteria set by the Joint Interim Statement.
Plasma DHPPA was inversely associated with MetS risk. After adjustment for age, sex, body mass index, smoking status, alcohol drinking status, physical activity and education level, the odds ratios (ORs) for MetS across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.86 (0.58-1.26), 0.77 (0.52-1.15), and 0.59 (0.39-0.89), respectively. In addition, the cubic spline analysis revealed a potential nonlinear association between plasma DHPPA and MetS, with a steep reduction in the risk at the lower range of plasma DHPPA concentration.
Our study revealed that individuals with higher DHPPA concentrations in plasma had lower odds of MetS compared to those with lower DHPPA concentrations in plasma. Our findings provided further evidence to support health benefits of whole grain consumption.
通过自我报告的方法评估的全谷物摄入量与代谢综合征（MetS）风险在流行病学研究中呈负相关。然而，很少有研究使用全谷物摄入量的客观生物标志物来评估全谷物摄入量与 MetS 风险之间的关系。本研究旨在检验血浆 3-(3,5-二羟苯基）-1-丙酸（DHPPA），一种全谷物小麦和黑麦摄入量的生物标志物，与中国人群 MetS 风险之间的关系。
基于同济-鄂州队列研究的基线数据，进行了一项 667 例 MetS 病例和 667 例匹配对照的病例对照研究。采用高效液相色谱-串联质谱法测定血浆 DHPPA 浓度。MetS 根据联合临时声明设定的标准定义。
血浆 DHPPA 与 MetS 风险呈负相关。在校正年龄、性别、体重指数、吸烟状况、饮酒状况、身体活动和教育水平后，血浆 DHPPA 浓度递增四分位数的 MetS 比值比（ORs）分别为 1（参照）、0.86（0.58-1.26）、0.77（0.52-1.15）和 0.59（0.39-0.89）。此外，三次样条分析显示血浆 DHPPA 与 MetS 之间存在潜在的非线性关系，在血浆 DHPPA 浓度较低的范围内，风险急剧降低。
我们的研究表明，与血浆中 DHPPA 浓度较低的个体相比，血浆中 DHPPA 浓度较高的个体患 MetS 的几率较低。我们的研究结果提供了进一步的证据，支持全谷物消费的健康益处。
