Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Viruses. 2021 Dec 15;13(12):2516. doi: 10.3390/v13122516.
Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, the enzymatic pathways to synthesize and metabolize inositol phosphates (IPs) relevant to retroviral assembly are discussed. The functions of these enzymes and IPs are outlined in the context of the cellular biology important for retroviruses. Lastly, the recent advances in understanding the role of IPs in retroviral biology are surveyed.
了解逆转录病毒组装的分子机制是一项长达数十年的努力。随着最近发现肌醇六磷酸（IP6）作为人类免疫缺陷病毒（HIV）的组装辅助因子，逆转录病毒研究取得了重大进展。在这篇综述中，讨论了与逆转录病毒组装相关的肌醇磷酸（IPs）的合成和代谢的酶途径。在对逆转录病毒重要的细胞生物学背景下，概述了这些酶和 IPs 的功能。最后，调查了最近在理解 IP 在逆转录病毒生物学中的作用方面的进展。
