Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Clinic of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Viruses. 2021 Dec 15;13(12):2517. doi: 10.3390/v13122517.
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
新生儿 COVID-19 罕见，主要由产后传播引起。然而，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）可感染胎盘并损害其功能。我们报告了两例轻度母体 COVID-19 后 5 天出现胎儿运动减少和胎儿心律异常的病例，分别在 29+3 周和 32+1 周时需要紧急剖宫产，导致脑损伤。胎盘检查显示广泛且多灶性的慢性绒毛膜炎，SARS-CoV-2 刺突抗体的细胞质呈强阳性，通过 RT-qPCR 检测到 SARS-CoV-2。在一例中证实了垂直传播，两名新生儿均出现广泛的囊状脑室周围白质软化。
