Su Chen-Ying, Yeh Lung-Kun, Tsao Yi-Fei, Lin Wen-Pin, Hou Chiun-Ho, Huang Hsueh-Fang, Lai Chi-Chun, Fang Hsu-Wei
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan.
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Taoyuan 333, Taiwan.
Polymers (Basel). 2021 Dec 9;13(24):4318. doi: 10.3390/polym13244318.
Orthokeratology lenses are commonly used for myopia control, especially in children. Tear lipids and proteins are immediately adsorbed when the lens is put on the cornea, and protein deposition may cause discomfort or infection. Therefore, we established an in vitro protein deposition analysis by mimicking the current cleaning methods for orthokeratology lens wearers for both short-term and long-term period. The results showed that the amounts of tear proteins accumulated daily and achieved a balance after 14 days when the lens was rubbed to clean or not. Protein deposition also affected the optical characteristics of the lens regardless of cleaning methods. Our results provided an in vitro analysis for protein deposition on the lens, and they may provide a potential effective method for developing care solutions or methods that can more effectively remove tear components from orthokeratology lenses.
角膜塑形镜常用于控制近视，尤其是在儿童中。当镜片置于角膜上时，泪液中的脂质和蛋白质会立即被吸附，蛋白质沉积可能会导致不适或感染。因此，我们通过模拟目前角膜塑形镜佩戴者的短期和长期清洁方法，建立了一种体外蛋白质沉积分析方法。结果表明，无论镜片是否被擦拭清洁，泪液蛋白质的积累量每天都在增加，并在14天后达到平衡。无论清洁方法如何，蛋白质沉积都会影响镜片的光学特性。我们的结果提供了一种镜片上蛋白质沉积的体外分析方法，它们可能为开发护理液或能更有效地从角膜塑形镜上去除泪液成分的方法提供一种潜在的有效方法。
