是史蒂文斯-约翰逊综合征还是伴有皮肤黏膜受累的儿童多系统炎症综合征？
Is It Stevens-Johnson Syndrome or MIS-C with Mucocutaneous Involvement?
作者信息
Karimi Abdollah, Pourbakhtiaran Elham, Fallahi Mazdak, Karbasian Fereshteh, Armin Shahnaz, Babaie Delara
机构信息
Pediatric Infections Research Center, Research Institute for Children's Health, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Department of Allergy and Clinical Immunology, Mofid Children's Hospital, ShahidBeheshti University of Medical Sciences, Tehran, IR, Iran.
出版信息
Case Rep Pediatr. 2021 Dec 24;2021:1812545. doi: 10.1155/2021/1812545. eCollection 2021.
BACKGROUND
Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) can be present in the form of multisystem inflammatory disease in children. . A 25-month-old boy presented with fever, malaise, diffuse maculopapular rashes, and mucosal involvement during the COVID-19 pandemic. He was first diagnosed with Stevens-Johnson syndrome (SJS). Further evaluation revealed lymphopenia, thrombocytopenia, and elevated levels of C-reactive protein (CRP), ferritin, and fibrinogen. This was followed by a positive polymerase chain reaction (PCR) test for COVID-19. In addition to receiving initial care for SJS, he was treated for MIS-C, which led to his recovery after four days.
CONCLUSION
COVID-19 infection should be considered in children with fever and dermatological features during the pandemic because it may cause different features of the multisystem inflammatory syndrome in children (MIS-C), suggestive of delayed hyperimmune response.
背景
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在儿童中可能以多系统炎症性疾病的形式出现。在新冠疫情期间，一名25个月大的男孩出现发热、不适、弥漫性斑丘疹和黏膜受累症状。他最初被诊断为史蒂文斯-约翰逊综合征（SJS）。进一步检查发现淋巴细胞减少、血小板减少，以及C反应蛋白（CRP）、铁蛋白和纤维蛋白原水平升高。随后新冠病毒聚合酶链反应（PCR）检测呈阳性。除了接受SJS的初始治疗外，他还接受了儿童多系统炎症综合征（MIS-C）的治疗，四天后康复。
结论
在疫情期间，对于出现发热和皮肤病学特征的儿童应考虑新冠病毒感染，因为它可能导致儿童多系统炎症综合征（MIS-C）的不同特征，提示免疫反应延迟增强。
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