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遗传学在高血压预防和治疗中的实际应用。

Practical applicability of genetics for the prevention and treatment of hypertension.

机构信息

Federal University of Paraíba/Department of Physical Education, Cidade Universitária, João Pessoa-PB, Brazil.

出版信息

J Clin Hypertens (Greenwich). 2022 Feb;24(2):119-121. doi: 10.1111/jch.14400. Epub 2021 Dec 28.

Abstract

Zou and colleagues are publishing in this issue of The Journal of Clinical Hypertension, result of one of their studies in which they found that human corin genetic polymorphisms is involved in blood pressure control, more specifically in salt sensitivity. It is being published in this journal shortly after a literature review indicated another 18 genes were also involved in salt sensitivity, however corin gene. This dynamism of newly discovered genes shows the complexity of studying the genetic control of arterial hypertension and explains its known preliotropic characteristic. In this commentary, the study by Zou and colleagues is placed in the context of recent evidence on the genetics of high blood pressure and the future perspectives resulting from this and other studies are presented in the context of the clinical application of genetics in the prevention and treatment of high blood pressure.

摘要

邹及其同事在本期《临床高血压杂志》上发表了他们的一项研究结果,该研究发现人类心钠肽原基因多态性与血压控制有关,更具体地说,与盐敏感性有关。就在该杂志发表这篇论文前不久,一篇文献综述表明,还有另外 18 个基因也与盐敏感性有关,但与心钠肽原基因无关。这些新发现基因的动态性表明,研究动脉高血压遗传控制的复杂性,并解释了其已知的前效特征。在这篇评论中,邹及其同事的研究置于高血压遗传学的最新证据背景下,并根据这一研究以及其他研究的结果,从高血压预防和治疗的遗传学临床应用的角度提出了未来的展望。

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本文引用的文献

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Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults.
J Clin Hypertens (Greenwich). 2021 Dec;23(12):2115-2123. doi: 10.1111/jch.14401. Epub 2021 Nov 30.
2
Pharmacogenomics of Hypertension Treatment.
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Omics of Blood Pressure and Hypertension.
Circ Res. 2018 May 11;122(10):1409-1419. doi: 10.1161/CIRCRESAHA.118.311342.
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Genetic factors contributing to hypertension in African-based populations: A systematic review and meta-analysis.
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Endothelial Dysfunction and Hypertension.
Adv Exp Med Biol. 2017;956:511-540. doi: 10.1007/5584_2016_90.

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