Antioxidant effects of diarylheptanoids from two species.

Five linear diarylheptanoids (), including a new one (), were isolated from the rhizomes of S. G. Lee et C. F. Liang, while four linear diarylheptanoids () and four cyclic diarylheptanoids () were isolated from the roots of Salisb. Using the model of HO-induced PC12 cells, the antioxidant effects of these thirteen diarylheptanoids from these two traditional Chinese medicines from genus of Zingiberaceae family were investigated. As result, they produced different efficiency on damaged cell viability, ROS, LDH, SOD, CAT, and GSH-Px, which were the six indexes related to oxidative stress. Further, the correlation between these six bio-indexes and 53 selected molecular descriptors of diarylheptanoids was determined by PLS regression analysis.