Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Pediatric Dentistry Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
BMC Oral Health. 2020 Nov 9;20(1):311. doi: 10.1186/s12903-020-01316-y.
Celiac disease (CD) is an immune-related enteropathy triggered by gluten ingestion in susceptible individuals. Oral manifestations of CD have been frequently described, although reports on dental maturity (DM) are scant. Thus, the aim of this study is to assess the prevalence of DM in CD patients and to test for possible predictors.
This is a case-control study of children with CD and healthy controls between 2017 and 2020. A panoramic radiograph and comprehensive oral examination were performed for each participant. Dental age (DA) was measured according to Demirjian's method and DM was calculated by subtracting the chronological age (CA) from the DA. Statistical analysis was performed to compare the DM between CD patients and controls, and a multivariate analysis was utilized to look for predictors of DM.
Two-hundred and eight participants (104 children with CD, and 104 healthy controls) were incorporated. The mean age for CD patients was 10.67 ± 2.40 years, and 10.69 ± 2.37 years for healthy controls (P = 0.971). CD patients had a higher prevalence of delayed DM than controls (62.5% vs. 3%, respectively). They also had a greater delay in DM than controls (- 7.94 ± 10.94 vs. 6.99 ± 8.77, P < 0.001). A multivariate analysis identified age between 6 and 7 years (β ± SE = 16.21 ± 2.58, P < 0.001), as the only predictor for DM.
CD patients had a greater prevalence of delayed DM than controls. No predictors for DM could be found, except young age.
乳糜泻（CD）是一种由敏感个体摄入麸质引起的与免疫相关的肠病。已经频繁描述了 CD 的口腔表现，尽管关于牙齿成熟度（DM）的报告很少。因此，本研究旨在评估 CD 患者 DM 的患病率，并检验可能的预测因素。
这是一项 2017 年至 2020 年间 CD 患者和健康对照者的病例对照研究。对每位参与者进行全景放射照相和全面口腔检查。根据 Demirjian 法测量牙龄（DA），并通过从 CA 中减去 DA 来计算 DM。进行统计分析以比较 CD 患者和对照组之间的 DM，并进行多变量分析以寻找 DM 的预测因素。
纳入了 208 名参与者（104 名 CD 患儿和 104 名健康对照者）。CD 患者的平均年龄为 10.67 ± 2.40 岁，健康对照组为 10.69 ± 2.37 岁（P = 0.971）。CD 患者 DM 延迟的发生率高于对照组（分别为 62.5%和 3%）。他们的 DM 延迟也比对照组更大（-7.94 ± 10.94 与 6.99 ± 8.77，P < 0.001）。多变量分析确定 6 至 7 岁之间的年龄（β ± SE = 16.21 ± 2.58，P < 0.001）是 DM 的唯一预测因素。
CD 患者 DM 延迟的发生率高于对照组。除了年龄较小外，未发现 DM 的预测因素。
