Medical Scientist Training Program.
Department of Psychiatry and Behavioral Health.
Alzheimer Dis Assoc Disord. 2022;36(2):173-175. doi: 10.1097/WAD.0000000000000485. Epub 2021 Dec 30.
It is becoming increasingly clear that the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 will have long-term negative consequences. Some patients report functional complaints long after recovery from coronavirus disease-2019 (COVID-19), which include fatigue, breathlessness, heart palpitations, loss or alteration of taste and smell, and problems with attention, memory, and cognition. However, the long-term complications for those patients who had severe symptoms and prolonged hypoxia during their course of their hospital stay is still unknown. We report 2 patients with confirmed diagnoses of COVID-19 who experienced prolonged infection and developed rapid progressive dementia following COVID-19 pneumonia after a follow-up period of 5 to 10 months. As these cases may become more prevalent over time, we should learn to recognize the early signs of long-term COVID-19 complications in those who are especially vulnerable to neurocognitive decline.
越来越明显的是，严重急性呼吸综合征冠状病毒 2 的全球爆发将产生长期的负面影响。一些患者在从 2019 冠状病毒病（COVID-19）中康复后很长一段时间仍报告有功能抱怨，包括疲劳、呼吸困难、心悸、味觉和嗅觉丧失或改变，以及注意力、记忆和认知问题。然而，对于那些在住院期间有严重症状和长时间缺氧的患者，其长期并发症仍不清楚。我们报告了 2 例确诊的 COVID-19 患者，他们在 COVID-19 肺炎后随访 5 至 10 个月时经历了长时间的感染，并出现快速进展性痴呆。随着时间的推移，这些病例可能会越来越普遍，我们应该学会识别那些特别容易出现神经认知能力下降的人在 COVID-19 长期并发症的早期迹象。
