Sun Tong, Yu Haiyang, Fu Jianhua
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Pediatr. 2021 Dec 13;9:762545. doi: 10.3389/fped.2021.762545. eCollection 2021.
Bronchopulmonary dysplasia (BPD) is a severe respiratory complication in preterm infants. Although the etiology and pathogenesis of BPD are complex and remain to be clarified, recent studies have reported a certain correlation between the microecological environment of the respiratory tract and BPD. Changes in respiratory tract microecology, such as abnormal microbial diversity and altered evolutional patterns, are observed prior to the development of BPD in premature infants. Therefore, research on the colonization and evolution of neonatal respiratory tract microecology and its relationship with BPD is expected to provide new ideas for its prevention and treatment. In this paper, we review microecological changes in the respiratory tract and the mechanisms by which they can lead to BPD in preterm infants.
支气管肺发育不良（BPD）是早产儿严重的呼吸系统并发症。尽管BPD的病因和发病机制复杂且有待阐明，但近期研究报道呼吸道微生态环境与BPD之间存在一定关联。在早产儿发生BPD之前，可观察到呼吸道微生态的变化，如微生物多样性异常和进化模式改变。因此，研究新生儿呼吸道微生态的定植与演变及其与BPD的关系，有望为其防治提供新思路。本文综述了早产儿呼吸道的微生态变化及其导致BPD的机制。
