Research Institute.
Mathison Centre for Mental Health Research and Education.
J Psychopathol Clin Sci. 2022 Feb;131(2):152-161. doi: 10.1037/abn0000732. Epub 2021 Dec 30.
This systematic review and meta-analysis updates evidence pertaining to response inhibition in obsessive-compulsive disorder (OCD) as measured by the stop-signal task (SST). We conducted a meta-analysis of the literature to compare response inhibition in patients with OCD and healthy controls, metaregressions to determine relative influences of age and sex on response inhibition performance, and a risk of bias assessment for included studies using the Newcastle-Ottawa Scale (NOS). Stop-signal reaction time (SSRT), which estimates the latency of the stopping process deficit, was significantly longer in OCD samples than in controls, reflecting inferior inhibitory control (Raw mean difference = 23.43 ms = <.001; 95% CI [17.42, 29.45]). We did not observe differences in mean reaction time (MRT) in OCD compared with controls (Raw mean difference = 2.51 ms = .755; 95% CI [-13.27, 18.30]). Reaction time variability (RTSD) was reported in one study only. Age impacted effect size of SSRT, indicating inferior performance in older OCD patients than younger ones. We did not observe a significant effect of sex on SSRT or MRT scores. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
本系统评价和荟萃分析更新了与强迫症 (OCD) 患者的反应抑制相关的证据，该研究采用停止信号任务 (SST) 进行测量。我们对文献进行荟萃分析，比较了 OCD 患者和健康对照组的反应抑制情况，进行元回归以确定年龄和性别对反应抑制表现的相对影响，并使用纽卡斯尔-渥太华量表 (NOS) 对纳入的研究进行偏倚风险评估。停止信号反应时间 (SSRT) 用于估计停止过程缺陷的潜伏期，在 OCD 样本中明显长于对照组，反映出抑制控制能力较差（原始平均差异 = 23.43 毫秒<.001；95%置信区间 [17.42, 29.45]）。我们没有观察到 OCD 组与对照组在平均反应时间 (MRT) 上的差异（原始平均差异 = 2.51 毫秒 =.755；95%置信区间 [-13.27, 18.30]）。只有一项研究报告了反应时间变异性 (RTSD)。年龄影响 SSRT 的效应大小，表明老年 OCD 患者的表现不如年轻患者。我们没有观察到性别对 SSRT 或 MRT 评分有显著影响。（PsycInfo 数据库记录（c）2022 APA，保留所有权利）。
