Pulmonary, Allergy, Critical Care, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
AIDS Res Hum Retroviruses. 2022 Feb;38(2):143-151. doi: 10.1089/AID.2021.0082.
People living with HIV (PLWH) have a higher prevalence of respiratory symptoms than people without human immunodeficiency virus (HIV). Antiretroviral therapy has been associated with worsened airflow limitation. This cross-sectional study assessed respiratory health impairment among PLWH and its association with protease inhibitor use using data from Multicenter AIDS Cohort Study visits between April 1, 2017 and March 31, 2018. Participants completed the St. George's Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) dyspnea scale, spirometry, and diffusion capacity measurement. Visit data were compared among PI users, non-PI users, and men without HIV. Binary and ordinal logistic models were used to determine the associations between HIV status, PI use, and covariates with primary outcomes of dichotomized SGRQ and mMRC dyspnea scores. Of PI users, 57/177 (32.2%) self-reported pulmonary disease compared with 132/501 (26.4%) of non-PI users and 105/547 (19.2%) men without HIV. Of PI users, 77/177 (45.3%) had SGRQ scores ≥10, while 171/501 (34.7%) of non-PI users and 162/549 (29.9%) of people living without HIV had SGRQ scores ≥10 ( = .001). Adjusted models found an association between PI use and SGRQ score ≥10 [odds ratio (OR) 1.91 (95% confidence interval [CI] 1.29-2.82), ref: HIV negative and OR 1.50 (95% CI 1.01-2.22) ref: non-PI users]. A similar association was found with mMRC scores and PI use [OR 1.79 (95% CI 1.21-2.64), ref: HIV negative and OR 1.53 (95% CI 1.04-2.25), ref: non-PI users]. PI use is associated with worse respiratory health status, increased dyspnea, and an increased prevalence of self-reported pulmonary disease.
艾滋病毒感染者（PLWH）的呼吸症状发生率高于未感染人类免疫缺陷病毒（HIV）的人。抗逆转录病毒治疗与气流受限恶化有关。本横断面研究使用 2017 年 4 月 1 日至 2018 年 3 月 31 日期间多中心艾滋病队列研究访问的数据，评估了 PLWH 的呼吸健康损害及其与蛋白酶抑制剂使用的关系。参与者完成了圣乔治呼吸问卷（SGRQ）、改良医学研究委员会（mMRC）呼吸困难量表、肺活量测定和扩散能力测量。比较了 PI 使用者、非 PI 使用者和无 HIV 的男性之间的就诊数据。使用二项和有序逻辑模型确定了 HIV 状态、PI 使用以及与主要结局（二分类 SGRQ 和 mMRC 呼吸困难评分）相关的协变量之间的关联。在 PI 使用者中，57/177（32.2%）自我报告患有肺部疾病，而 132/501（26.4%）非 PI 使用者和 105/547（19.2%）无 HIV 的男性中报告患有肺部疾病。在 PI 使用者中，77/177（45.3%）的 SGRQ 评分≥10，而 171/501（34.7%）非 PI 使用者和 162/549（29.9%）无 HIV 的人中，SGRQ 评分≥10（=0.001）。调整后的模型发现，PI 使用与 SGRQ 评分≥10 之间存在关联[比值比（OR）1.91（95%置信区间[CI]1.29-2.82），参考：HIV 阴性和 OR 1.50（95%CI 1.01-2.22），参考：非 PI 使用者]。与 PI 使用相关的 mMRC 评分也存在类似的关联[OR 1.79（95%CI 1.21-2.64），参考：HIV 阴性和 OR 1.53（95%CI 1.04-2.25），参考：非 PI 使用者]。PI 使用与呼吸健康状况恶化、呼吸困难增加和自我报告肺部疾病的患病率增加有关。
