Chen Ting-Ting, Lv Jia-Jun, Chen Ling, Gao Yu-Wei, Liu Li-Ping
The First Clinical Medical School of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Department of Emergency Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Exp Ther Med. 2022 Feb;23(2):119. doi: 10.3892/etm.2021.11042. Epub 2021 Dec 6.
Heparinase (HPA) is a β-D glucuronidase that belongs to the endoglycosidase enzyme family, and plays an important role in numerous pathological and physiological processes, including inflammation, angiogenesis and tumor metastasis. When the expression of HPA is abnormally high, the side chain of heparin sulfate proteoglycans degrades, destroying the cell barrier and leading to the occurrence and development of inflammation, with systemic inflammation occurring in severe cases. Sepsis is a major cause of mortality in critically ill patients. In sepsis, the gastrointestinal tract is the first and most frequently involved target organ, which often leads to gastrointestinal dysfunction. HPA overexpression has been determined to accelerate sepsis progression and gastrointestinal dysfunction; thus, it was hypothesized that HPA may play an important role and may serve as an index for the diagnosis of gastrointestinal dysfunction in sepsis. HPA inhibitors may therefore become applicable as targeted drugs for the treatment of gastrointestinal dysfunction in patients with sepsis. The present review mainly discussed the role of HPA in gastrointestinal dysfunction of sepsis.
肝素酶（HPA）是一种属于内切糖苷酶家族的β-D葡萄糖醛酸酶，在包括炎症、血管生成和肿瘤转移在内的众多病理和生理过程中发挥重要作用。当HPA表达异常升高时，硫酸乙酰肝素蛋白聚糖的侧链降解，破坏细胞屏障，导致炎症的发生和发展，严重时会出现全身炎症。脓毒症是危重症患者死亡的主要原因。在脓毒症中，胃肠道是首个且最常受累的靶器官，常导致胃肠功能障碍。已确定HPA过表达会加速脓毒症进展和胃肠功能障碍；因此，有人推测HPA可能起重要作用，并可能作为脓毒症胃肠功能障碍诊断的一个指标。因此，HPA抑制剂可能成为治疗脓毒症患者胃肠功能障碍的靶向药物。本综述主要讨论了HPA在脓毒症胃肠功能障碍中的作用。
