Kheyrandish Setare, Rastgar Amirhossein, Arab-Zozani Morteza, Sarab Gholamreza Anani
Department of Hematology and Blood Banking, School of Paramedical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Front Med (Lausanne). 2021 Dec 14;8:794599. doi: 10.3389/fmed.2021.794599. eCollection 2021.
Infection by the novel coronavirus disease 2019 (COVID-19) has been associated with different types of thrombotic complications same as portal vein thrombosis (PVT). However, by emerging vaccines of COVID, the thrombosis did not seem to be concerning anymore. Until new findings showed that, the vaccine of COVID itself can cause PVT. We performed an electronic search in PubMed, Scopus, and Web of Sciences to evaluate the possibility of occurring PVT due to infection and vaccination of COVID-19. The results were reported in a narrative method and categorized into tables. Overall, 40 cases of PVT from 34 studies were reviewed in this article. The prevalence of PVT following COVID-19 was more remarkable in males. However, it was more common in females after vaccinations of COVID-19 in the reviewed cases. Regardless of etiology, 20 of PVT cases reviewed in this article had at least one comorbidity. The most common clinical presentation was abdominal pain (AP). After anticoagulant therapies, most of the patients improved or discharged. As long as the laboratory findings are not appropriate enough to predict PVT, the diagnosis of this complication with whatever underlying reason is challengeable, while rapid diagnosis and treatment of that are vital. Therefore, by providing available data in an organized way, we aimed to prepare the information of infected patients for better and easier future diagnosis of PVT in new cases.
2019年新型冠状病毒病（COVID-19）感染与不同类型的血栓形成并发症相关，门静脉血栓形成（PVT）亦是如此。然而，随着新冠疫苗的出现，血栓形成似乎不再令人担忧。直到新的研究结果表明，新冠疫苗本身可导致PVT。我们在PubMed、Scopus和科学网进行了电子检索，以评估COVID-19感染和接种疫苗导致PVT发生的可能性。结果以叙述方式报告并整理成表格。本文共回顾了34项研究中的40例PVT病例。COVID-19感染后PVT的患病率在男性中更为显著。然而，在所回顾的病例中，COVID-19疫苗接种后PVT在女性中更为常见。无论病因如何，本文回顾的PVT病例中有20例至少合并有一种疾病。最常见的临床表现是腹痛（AP）。经过抗凝治疗后，大多数患者病情改善或出院。由于实验室检查结果不足以充分预测PVT，无论其潜在原因如何，对这种并发症的诊断都具有挑战性，而快速诊断和治疗至关重要。因此，通过以有组织的方式提供现有数据，我们旨在为受感染患者提供信息，以便在未来新病例中更好、更轻松地诊断PVT。
