Department of Pediatric Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho Showa-ku, Nagoya-shi, Aichi, 466-8650, Japan.
Department of Pediatrics, Ichinomiya Medical Treatment and Habilitation Center, 1679-2 Tomida-nagaresuji, Ichinomiya-shi, Aichi, 494-0018, Japan.
Clin Exp Nephrol. 2022 Mar;26(3):266-271. doi: 10.1007/s10157-021-02165-x. Epub 2022 Jan 1.
We have developed a simple and easy method of estimating the glomerular filtration rate (eGFR) of serum creatinine in Japanese children (eGFR). The eGFR equation is for children aged 2-18 years. Therefore Uemura et al. developed an equation for children younger than 2 years (eGFR). The aim of the present study was to validate this new equation.
We collected the data of 13 patients from previous studies and compared the results of eGFR, eGFR, and updated eGFR developed by Schwartz (eGFR) with measured GFR using mean error (ME), root mean square error (RMSE), P and Bland-Altman analysis.
The ME of eGFR, eGFR and eGFR were 2.3 ± 15.9, 7.7 ± 14.5, and 16.0 ± 18.2 ml/min/1.73m, respectively. The RMSEs were 15.5, 15.9, and 49.6, respectively. The P values were 76.9%, 76.9%, and 53.8%, respectively. The graph of Bland-Altman bias analysis showed fan-shape. The eGFR equation was the most accurate in the three equations.
The eGFR equation was useful for Japanese children younger than 2 years.
我们已经开发出一种简单易用的方法来估算日本儿童的血清肌酐肾小球滤过率（eGFR）（eGFR）。eGFR 方程适用于 2-18 岁的儿童。因此，Uemura 等人开发了适用于 2 岁以下儿童的方程（eGFR）。本研究的目的是验证这个新方程。
我们收集了之前研究中的 13 名患者的数据，并将 eGFR、eGFR 和 Schwartz 开发的更新的 eGFR（eGFR）与使用平均误差（ME）、均方根误差（RMSE）、P 和 Bland-Altman 分析测量的 GFR 的结果进行了比较。
eGFR、eGFR 和 eGFR 的 ME 分别为 2.3±15.9、7.7±14.5 和 16.0±18.2ml/min/1.73m。RMSE 分别为 15.5、15.9 和 49.6。P 值分别为 76.9%、76.9%和 53.8%。Bland-Altman 偏倚分析图显示为扇形。在这三个方程中，eGFR 方程最准确。
eGFR 方程适用于 2 岁以下的日本儿童。
