Franchini G, Collalti E, Arya S K, Fenyö E M, Biberfeld G, Zagury J F, Kanki P J, Wong-Staal F, Gallo R C
AIDS Res Hum Retroviruses. 1987 Spring;3(1):11-7. doi: 10.1089/aid.1987.3.11.
A new primate retrovirus, STLV-IIIAGM, has been recently isolated from healthy African green monkeys and is apparently nonpathogenic in its natural host. However, spontaneous infection as well as inoculation of STLV-IIIAGM into macaques induces a disease with clinical features that resemble human AIDS. Independent isolates of human retroviruses, serologically closely related to STLV-IIIAGM, have been obtained from healthy individuals (HTLV-IV) and patients with immunodeficiency (LAV-2FG and SBL 6669) from West Africa. The latter have also been referred to as HIV-2 because, like HTLV-III/HIV-1, they may be associated with immune deficiency, or as West African human retroviruses because of their prevalence and probable origin from that region. We have molecularly cloned the STLV-IIIAGM genome and have generated probes from the gag-pol and envelope genes to analyze the genetic relatedness of these simian and human retroviruses. Our results indicate that all these retroviruses are genetically closely related to each other, HTLV-IV and STLV-IIIAGM differing only by a few restriction enzyme sites while LAV-2FG and SBL 6669 exhibit greater polymorphism from HTLV-IV/STLV-IIIAGM. These data mirror the variable degree of relatedness among members of the first subgroup of human retroviruses, HTLV-III/HIV.
一种新的灵长类逆转录病毒，即猴嗜T淋巴细胞病毒Ⅲ型非洲绿猴株（STLV - IIIAGM），最近从健康的非洲绿猴中分离出来，在其自然宿主中显然无致病性。然而，STLV - IIIAGM的自发感染以及接种到猕猴体内会引发一种疾病，其临床特征类似于人类艾滋病。已从健康个体（HTLV - IV）以及西非免疫缺陷患者（LAV - 2FG和SBL 6669）中获得了与STLV - IIIAGM血清学密切相关的人类逆转录病毒独立分离株。后者也被称为HIV - 2，因为它们像HTLV - III/HIV - 1一样，可能与免疫缺陷有关，或者由于其在该地区的流行情况以及可能的起源而被称为西非人类逆转录病毒。我们已经对STLV - IIIAGM基因组进行了分子克隆，并从gag - pol和包膜基因生成了探针，以分析这些猿猴和人类逆转录病毒的遗传相关性。我们的结果表明，所有这些逆转录病毒在遗传上彼此密切相关，HTLV - IV和STLV - IIIAGM仅在几个限制性酶切位点上有所不同，而LAV - 2FG和SBL 6669与HTLV - IV/STLV - IIIAGM相比表现出更大的多态性。这些数据反映了人类逆转录病毒第一亚组成员，即HTLV - III/HIV之间不同程度的相关性。
