Cummings School of Veterinary Medicine (Benedict), Foster Hospital for Small Animals (Mahony), Tufts University, 200 Westboro Road, North Grafton, Massachusetts 01536, USA; VCA Clinical Studies, 12401 West Olympic Blvd, Los Angeles, California 90064, USA (McKee, Bergman).
Can J Vet Res. 2022 Jan;86(1):52-58.
The aim of this study was to investigate the effect of bexagliflozin on glycemic control in poorly regulated diabetic cats and to evaluate for adverse events associated with this medication. Sodium-glucose cotransporter 2 inhibitors are a newer class of drugs used in the management of humans with type 2 diabetes mellitus. The objective of this study was to evaluate the effect of the orally administered drug, bexagliflozin in a group of poorly regulated diabetic cats over a 4-week study period. Five client-owned cats with poorly controlled diabetes mellitus receiving insulin therapy were enrolled. Bexagliflozin was administered once daily. Serum fructosamine, serum biochemistry profile, and 10-hour blood glucose curves were assessed at baseline (Day 0), Day 14, and Day 28. All cats had a significant reduction in insulin dose requirement ( = 0.015) and insulin was discontinued in 2 cats. There was a significant decrease in blood glucose concentration obtained from blood glucose concentration curves during the study period ( = 0.022). Serum fructosamine decreased in 4 of the 5 cats with a median decrease of 152 μmol/L (range: 103 to 241 μmol/L), which was not statistically significant ( = 0.117). No cats had any documented episodes of hypoglycemia. Adverse effects were mild. The addition of bexagliflozin significantly improved diabetic management in this group of cats.
本研究旨在探讨贝格列净对血糖控制不佳的糖尿病猫的疗效，并评估与该药物相关的不良反应。钠-葡萄糖共转运蛋白 2 抑制剂是一种新型药物，用于治疗 2 型糖尿病患者。本研究旨在评估口服药物贝格列净在一组血糖控制不佳的糖尿病猫中的疗效，研究时间为 4 周。纳入了 5 只接受胰岛素治疗的血糖控制不佳的糖尿病猫。贝格列净每天给药一次。在基线（第 0 天）、第 14 天和第 28 天评估血清果糖胺、血清生化谱和 10 小时血糖曲线。所有猫的胰岛素剂量需求均显著降低（=0.015），其中 2 只猫停止使用胰岛素。研究期间，血糖浓度曲线的血糖浓度显著降低（=0.022）。5 只猫中有 4 只的血清果糖胺降低，中位数降低 152 μmol/L（范围：103 至 241 μmol/L），但无统计学意义（=0.117）。没有猫出现任何记录的低血糖发作。不良反应轻微。贝格列净的添加显著改善了这群猫的糖尿病管理。
