Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia.
Libyan J Med. 2010 Feb 8;5. doi: 10.3402/ljm.v5i0.4847.
So far no studies have been performed in Malaysia to look at association of diabetes mellitus (DM) with blood groups. We studied the association of ABO blood groups with DM type 2.
It was a case control study conducted at Kepala Batas Hospital Batas, Penang, Malaysia in the year 2009, involving 70 patients with DM type 2 and 140 healthy controls. Ethical approval was obtained from Universiti Sains Malaysia. Blood samples were collected from the patients after consent. Samples were tested for ABO blood groups using ID-Card gel method.
Chi-square test results showed that there was an association between the ABO blood groups and DM type 2. It was found that A and O blood groups were negatively associated with DM type 2 (P<0.05) with higher percentage of A and O groups individuals were non-diabetic. No significant association was noted between DM type 2 and blood groups B (P=0.423) and AB (P=0.095). It was also noted that B blood group was distributed with highest percentage among patients with DM type 2 (53.71%) compared to controls (22.52%), but no statistical significance achieved.
The results obtained suggest that there was a negative association between ABO blood groups A and O with DM type 2, with A and O group having less chances of diabetes. Large studies in other ethnic groups are needed to confirm these results.
目前在马来西亚还没有研究探讨糖尿病（DM）与血型之间的关联。我们研究了 AB0 血型与 2 型糖尿病之间的关联。
这是 2009 年在马来西亚槟城巴东勿刹的 Kepala Batas 医院进行的病例对照研究，共纳入 70 例 2 型糖尿病患者和 140 名健康对照者。该研究获得了马来西亚理科大学的伦理批准。征得患者同意后采集其血液样本。使用 ID-Card 凝胶法检测 ABO 血型。
卡方检验结果显示，AB0 血型与 2 型糖尿病之间存在关联。结果发现，A 型和 O 型血与 2 型糖尿病呈负相关（P<0.05），A 型和 O 型血个体患糖尿病的比例较低。B 型血（P=0.423）和 AB 型血（P=0.095）与 2 型糖尿病之间无显著关联。还注意到，与对照组（22.52%）相比，2 型糖尿病患者中 B 型血的分布比例最高（53.71%），但未达到统计学意义。
研究结果表明，AB0 血型 A 和 O 与 2 型糖尿病之间呈负相关，A 型和 O 型血患糖尿病的几率较低。需要在其他种族群体中进行更大规模的研究来验证这些结果。
