Department of Medicine, University of Washington, Seattle, Washington, USA.
Department of Radiology, University of Washington, Seattle, Washington, USA.
Alzheimers Dement. 2022 Oct;18(10):1898-1906. doi: 10.1002/alz.12527. Epub 2022 Jan 3.
Older adults with cognitive impairment, including those with Alzheimer's disease and related dementias, are particularly at risk for hospitalization and hospital-associated disability. Understanding of key risk factors for hospital-associated disability is limited. Sarcopenia, age-related declines in muscle mass and strength, is common in older adults with cognitive impairment and may be an important risk factor for hospital-associated disability.
Using data from the Health ABC Study, we examined associations of pre-hospitalization appendicular lean mass (ALM) and grip strength with the development of a new activity of daily living (ADL) disability at the next annual assessment after hospitalization.
Grip strength, but not ALM, was negatively associated with increased risk of hospital-associated ADL disability, and this association was greater among those with cognitive impairment compared to those without.
Lower grip strength may be an important risk factor for hospital-associated ADL disability in older adults, particularly those with cognitive impairment.
认知障碍的老年人，包括患有阿尔茨海默病和相关痴呆症的老年人，特别容易住院和出现与住院相关的残疾。对于与住院相关的残疾的关键风险因素的了解有限。肌少症，即与年龄相关的肌肉质量和力量下降，在认知障碍的老年人中很常见，可能是与住院相关的残疾的一个重要风险因素。
利用健康老龄化、身体成分和认知研究的数据，我们研究了住院前四肢瘦体重（ALM）和握力与住院后下一年年度评估中出现新的日常生活活动（ADL）残疾的发展之间的关联。
握力而非 ALM 与与住院相关的 ADL 残疾风险增加呈负相关，且在认知障碍患者中这种关联比在无认知障碍患者中更大。
较低的握力可能是老年认知障碍患者与住院相关的 ADL 残疾的一个重要风险因素。
