Department of Cardiovascular Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Int J Cardiol. 2022 Mar 1;350:111-117. doi: 10.1016/j.ijcard.2021.12.056. Epub 2021 Dec 31.
Poor oral care is associated with cardiovascular disease. The aim of this study was to determine the impact of tooth brushing behavior on the incidences of future cardiovascular events in a general population including patients with cardiovascular disease.
This was a prospective observational study which included 692 participants (437 men and 255 women, mean age, 63 ± 16 years). The participants were divided into three groups according to the frequency and duration of tooth brushing: low frequency and short duration group (<twice/day and <2 min/procedure), low frequency or short duration group (<twice/day or <2 min/procedure), and non-low frequency and non-short duration group (≥twice/day and ≥2 min/procedure). We assessed the associations of tooth brushing behavior with major adverse cardiovascular events (MACEs) including death from cardiovascular causes, acute myocardial infarction, hospitalization for heart failure, and stroke.
During a median follow-up period of 28.5 (15.4-35.1) months, 32 events occurred (10 deaths from cardiovascular causes, one acute myocardial infarction, 13 hospitalizations for heart failure, and eight strokes). Kaplan-Meier curves for MACEs among the groups were significantly different (P = 0.001). After adjustment for cardiovascular risk factors, the combination of low frequency and short duration of tooth brushing was significantly associated with high incidences of MACEs compared with the incidences of MACEs for the combination of non-low frequency and non-short duration of tooth brushing (hazard ratio, 3.06; 95% confidence interval, 1.24-7.63; P = 0.02).
The combination of decreased frequency and duration of tooth brushing is associated with a higher risk of cardiovascular events.
URL for Clinical Trial: http://UMIN; Registration Number for Clinical Trial: UMIN000003409.
口腔护理不佳与心血管疾病有关。本研究旨在确定刷牙行为对包括心血管疾病患者在内的一般人群未来心血管事件发生率的影响。
这是一项前瞻性观察研究，共纳入 692 名参与者（437 名男性和 255 名女性，平均年龄 63±16 岁）。根据刷牙频率和时长，将参与者分为三组：低频率短时长组（<每天两次且每次刷牙<2 分钟）、低频率或短时长组（<每天两次或每次刷牙<2 分钟）、非低频率非短时长组（每天刷牙≥两次且每次刷牙≥2 分钟）。我们评估了刷牙行为与主要不良心血管事件（MACE）的相关性，MACE 包括心血管原因导致的死亡、急性心肌梗死、心力衰竭住院和中风。
在中位随访 28.5（15.4-35.1）个月期间，发生了 32 例事件（10 例心血管原因死亡、1 例急性心肌梗死、13 例心力衰竭住院、8 例中风）。各组间 MACE 的 Kaplan-Meier 曲线差异有统计学意义（P=0.001）。在调整心血管危险因素后，与非低频率非短时长刷牙组合相比，低频率短时长刷牙组合与 MACE 发生率较高显著相关（风险比，3.06；95%置信区间，1.24-7.63；P=0.02）。
刷牙频率和时长的减少与心血管事件风险的增加相关。
