Tang Zihan, Qiu Tian, Ma Runfeng, Wang Ruoyu, Wang Bingqian, Lu Yiduo, Huang Bi, Luo Suxin, Liu Gang
Chongqing Medical University, Chongqing, China.
Naval Medical University, Shanghai, China.
Sci Rep. 2025 May 27;15(1):18463. doi: 10.1038/s41598-025-01910-6.
Coronary artery disease (CAD) is a prevalent and high-mortality condition globally. The awareness regarding adequate oral care in China was insufficient. This study investigates the outcomes of CAD patients in southwest China based on their tooth brushing frequency. A total of 841 CAD patients were selected from a cohort of 32,709 residents. Over a four-year follow-up period, the incidence of three-point major adverse cardiovascular events (3P-MACEs) was evaluated. The results indicated that the hazard ratios (HR) with 95% confidence intervals (CIs) for 3P-MACEs among the three groups of tooth brushing frequency (twice, once, and thrice daily) were: reference, 1.61 (1.09-2.37) (p = 0.017), and 0.49 (0.15-1.62) (p = 0.241). Patients who brushed their teeth only once a day had a 1.71 (1.18-2.46) times higher risk compared to those who brushed twice or more daily (p = 0.004). In conclusion, insufficient tooth brushing frequency appears to be associated with a higher risk of adverse outcomes among CAD patients.
冠状动脉疾病（CAD）在全球范围内是一种普遍且死亡率高的疾病。在中国，对于充足口腔护理的认知不足。本研究基于刷牙频率调查了中国西南部CAD患者的预后情况。从32709名居民队列中选取了841名CAD患者。在四年的随访期内，评估了三点主要不良心血管事件（3P-MACEs）的发生率。结果表明，三组刷牙频率（每天两次、一次和三次）的3P-MACEs的风险比（HR）及其95%置信区间（CI）分别为：参照组、1.61（1.09 - 2.37）（p = 0.017）和0.49（0.15 - 1.62）（p = 0.241）。与每天刷牙两次或更多次的患者相比，每天仅刷牙一次的患者风险高1.71（1.18 - 2.46）倍（p = 0.004）。总之，刷牙频率不足似乎与CAD患者不良预后风险较高相关。
