Pan Yuhao, Shi Peiyan, Pu Liuyi, Song Donglai, Lu Jiaping, Hou Wenjie, Tang Kangjian
Innovation Center for Chemical Sciences, College of Chemistry, Chemical Engineering and Materials Science, Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Soochow University Suzhou 215123 People's Republic of China
Dental Clinic of Xuhui District Shanghai 200031 People's Republic of China
RSC Adv. 2025 May 9;15(19):15266-15275. doi: 10.1039/d5ra00313j. eCollection 2025 May 6.
Open fracture surgery is one of the common emergency procedures in orthopedics. It requires effective postoperative management, including anti-inflammatory and antimicrobial measures, as well as promotion of bone cell growth. Due to the higher risk of infection and challenges in fracture healing associated with open fractures, the development of effective long-acting postoperative therapeutic drug delivery materials is crucial. In this study, we demonstrate the development of one spontaneous administration for the postoperative maintenance and treatment of open fractures. By integrating medicine-loaded mesoporous molecular sieves (MMMSs) with hydrogels, a composite material termed nanoporous medicine composite hydrogel (NMCH) was formulated. Through adjusting the proportions of hydrogel monomers and molecular sieves, this material attained mechanical properties akin to periosteum. Physicochemical studies including XRD, SEM, TEM, UV absorption, and N adsorption confirmed excellent drug-loading capabilities of the composite material. Furthermore, antibacterial experiments, cell proliferation assays, and mouse paw edema tests validated significant effects of the drug-loaded composite material in antibacterial activity, promotion of osteoblast growth, and anti-inflammatory properties, demonstrating its enormous potential and application value in postoperative treatment of open fractures.
开放性骨折手术是骨科常见的急诊手术之一。它需要有效的术后管理，包括抗炎和抗菌措施，以及促进骨细胞生长。由于开放性骨折感染风险较高且骨折愈合面临挑战，开发有效的长效术后治疗药物递送材料至关重要。在本研究中，我们展示了一种用于开放性骨折术后维持和治疗的自发给药方法。通过将载药介孔分子筛（MMMSs）与水凝胶相结合，制备了一种称为纳米多孔药物复合水凝胶（NMCH）的复合材料。通过调整水凝胶单体和分子筛的比例，该材料获得了类似于骨膜的机械性能。包括XRD、SEM、TEM、紫外吸收和氮吸附在内的物理化学研究证实了该复合材料具有优异的载药能力。此外，抗菌实验、细胞增殖测定和小鼠爪肿胀试验验证了载药复合材料在抗菌活性、促进成骨细胞生长和抗炎特性方面的显著效果，证明了其在开放性骨折术后治疗中的巨大潜力和应用价值。
