Andersen Mads, Pedersen Mette Vestergård, Andelius Ted Carl Kejlberg, Kyng Kasper Jacobsen, Henriksen Tine Brink
Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Front Pediatr. 2021 Dec 20;9:787804. doi: 10.3389/fped.2021.787804. eCollection 2021.
Studies have suggested that neurological outcome may differ in newborns with encephalopathy with and without perinatal infection. We aimed to systematically review this association. We conducted this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies were obtained from four databases including Pubmed, Embase, Web of Science, and The Cochrane Database. Newborns with encephalopathy with and without markers of perinatal infection were compared with regard to neurodevelopmental assessments, neurological disorders, and early biomarkers of brain damage. Risk of bias and quality of evidence were assessed by the Newcastle-Ottawa scale and Grading of Recommendations Assessment, Development and Evaluation (GRADE). We screened 4,284 studies of which eight cohort studies and one case-control study met inclusion criteria. A narrative synthesis was composed due to heterogeneity between studies. Six studies were classified as having low risk of bias, while three studies were classified as having high risk of bias. Across all outcomes, the quality of evidence was very low. The neurological outcome was similar in newborns with encephalopathy with and without markers of perinatal infection. Further studies of higher quality are needed to clarify whether perinatal infection may affect neurological outcome following newborn encephalopathy. https://www.crd.york.ac.uk/prospero/, identifier CRD42020185717.
研究表明，患有脑病的新生儿中，有围产期感染和无围产期感染的神经学转归可能有所不同。我们旨在对这种关联进行系统评价。我们根据系统评价和Meta分析的首选报告项目（PRISMA）进行了这项系统评价。研究从四个数据库中获取，包括PubMed、Embase、科学网和考克兰数据库。对患有脑病且有和没有围产期感染标志物的新生儿在神经发育评估、神经疾病和脑损伤早期生物标志物方面进行了比较。采用纽卡斯尔-渥太华量表和推荐分级的评估、制定与评价（GRADE）对偏倚风险和证据质量进行了评估。我们筛选了4284项研究，其中八项队列研究和一项病例对照研究符合纳入标准。由于各研究之间存在异质性，因此进行了叙述性综合分析。六项研究被归类为偏倚风险低，而三项研究被归类为偏倚风险高。在所有结局方面，证据质量都非常低。患有脑病且有和没有围产期感染标志物的新生儿的神经学转归相似。需要开展更高质量的进一步研究，以阐明围产期感染是否可能影响新生儿脑病后的神经学转归。https://www.crd.york.ac.uk/prospero/，标识符CRD42020185717。
