Department of Dermatology, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Photodermatol Photoimmunol Photomed. 2022 Jul;38(4):382-390. doi: 10.1111/phpp.12765. Epub 2022 Jan 21.
Despite the widespread use of intense pulsed light (IPL) technology in cosmetic dermatology, the effects of its repeated use on facial skin sensitivity in healthy individuals remains unknown.
Seventeen healthy female volunteers were included in the study. We measured objective biophysical parameters of the skin, including transepidermal water loss (TEWL), skin glossiness, thickness and density of the epidermis and dermis, sensory nerve current perception threshold (CPT), and regional blood flow before and after treatment at different time points.
Sixteen volunteers completed a follow-up of 12 months. The treated side of the face showed a decreased TEWL on D1 and D3, which reverted to normal on D7. Epidermal thickness increased and skin glossiness decreased on the treated side on D1, but returned to normal on D3. We found no statistically significant differences in CPT values or in regional blood flow volume and velocity, with the exception of D1, which exhibited a higher regional blood flow volume on the treated side.
Repeated IPL treatments had no effects on facial skin barrier function, skin nerve sensitivity, or local microcirculation among healthy individuals. IPL is a safe skin care procedure that does not affect skin sensitivity.
尽管强脉冲光 (IPL) 技术在美容皮肤科中被广泛应用，但在健康个体中，其重复使用对面部皮肤敏感性的影响尚不清楚。
本研究纳入了 17 名健康女性志愿者。我们测量了皮肤的客观生物物理参数，包括经表皮水分流失（TEWL）、皮肤光泽度、表皮和真皮的厚度和密度、感觉神经电流感知阈值（CPT）以及治疗前后不同时间点的局部血流。
16 名志愿者完成了 12 个月的随访。治疗侧面部在 D1 和 D3 时 TEWL 降低，在 D7 时恢复正常。治疗侧表皮厚度在 D1 时增加，皮肤光泽度降低，但在 D3 时恢复正常。我们发现 CPT 值或局部血流体积和速度没有统计学上的显著差异，除了 D1 时治疗侧的局部血流体积较高。
在健康个体中，重复 IPL 治疗对皮肤屏障功能、皮肤神经敏感性或局部微循环没有影响。IPL 是一种安全的皮肤护理程序，不会影响皮肤敏感性。
