College of Marine Life Sciences, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong Province, PR China.
Shandong Gold Group Co., Ltd., PR China.
Mar Pollut Bull. 2022 Jan;174:113289. doi: 10.1016/j.marpolbul.2021.113289. Epub 2022 Jan 3.
Microplastics and polychlorinated biphenyls are ubiquitous in the marine environments. To illuminate their combined biological impacts, juvenile Japanese flounder (Paralichthys olivaceus) were exposed to 500 ng/L PCBs alone or 500 ng/L PCBs plus 2, 20, and 200 μg/L 10-μm porous MPs for 21 days. Compared to PCBs alone, co-exposure to PCBs and 20, 200 μg/L MPs reduced fish body length and body weight, and the concurrence of MPs aggravated PCBs-induced thyroid-disrupting effects, including significantly decreased L-thyroxine and L-triiodothyronine levels, more severe damage to the thyroid tissue and gill morphology, and disturbance on the expression of hypothalamus-pituitary-thyroid axis genes. The PCBs concentrations in the seawater were decreased dramatically with the increase of MPs concentrations, confirming that MPs absorbed PCBs from the seawater. Our results demonstrated that MPs enhanced the thyroid disruption of PCBs, suggesting that the risk of MPs and thyroid-disrupting chemicals on marine organisms should be paid more attention.
微塑料和多氯联苯在海洋环境中无处不在。为了阐明它们的联合生物影响，将幼年日本牙鲆（Paralichthys olivaceus）暴露于 500ng/L 单独 PCBs 或 500ng/L PCBs 加 2、20 和 200μg/L 10μm 多孔 MPs 中 21 天。与单独暴露于 PCBs 相比，同时暴露于 PCBs 和 20、200μg/L MPs 会降低鱼体长度和体重，并且 MPs 的并发会加剧 PCBs 引起的甲状腺破坏作用，包括 L-甲状腺素和 L-三碘甲状腺原氨酸水平显著降低，甲状腺组织和鳃形态的更严重损伤，以及下丘脑-垂体-甲状腺轴基因表达的紊乱。随着 MPs 浓度的增加，海水中的 PCBs 浓度显著降低，证实 MPs 从海水中吸收了 PCBs。我们的结果表明 MPs 增强了 PCBs 对甲状腺的破坏作用，表明海洋生物中 MPs 和甲状腺破坏化学物质的风险应该引起更多关注。
