Department of Pediatrics, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil; Programa de Pós-Graduação em Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Department of Pediatrics, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
An Bras Dermatol. 2022 Mar-Apr;97(2):173-178. doi: 10.1016/j.abd.2021.03.010. Epub 2022 Jan 3.
The prevalence of atopic eczema is unknown in many countries. The International Study of Asthma and Allergies in Childhood (ISAAC) is an epidemiological landmark in the study of allergic diseases.
To validate and assess the reproducibility of the ISAAC Written Atopic Eczema Questionnaire (WAEQ) for children aged between 6 and 7 years by telephone contact.
Observational study through interviews with guardians of children aged 6 to 7 years using the ISAAC atopic eczema module questionnaire in three different phases separated by 2 weeks: telephone interviews in the first and third contacts and in-person interviews under supervision in the second contact. Reproducibility was estimated using the Kappa index and validation using the sensitivity and specificity coefficients.
Data from 88 children (32 from the atopic eczema group) were analyzed. Reproducibility showed almost perfect agreement for the questions "Recurrent pruritic lesions" and "Lesions in typical locations" (Kappa between 0.81-0.82), while a substantial agreement was observed for all other indicators (Kappa variation between 0.66 and 0.78). The validation showed high specificity (≥ 80.4%) and sensitivity (≥ 87.5%) for all questions, except those related to chronicity and medical diagnosis (34.4% and 40.6%, respectively).
Non-random selection, no sample size calculation, participants from a tertiary hospital and study period coincident with the Coronavirus pandemic.
Our results showed that the ISAAC atopic eczema module questionnaire by telephone interviews has good reproducibility and high agreement with the clinical diagnosis of atopic eczema. It may be an appropriate alternative tool in epidemiological studies of childhood atopic eczema, especially in periods of social isolation.
许多国家都不清楚特应性皮炎的流行情况。国际儿童哮喘和过敏研究（ISAAC）是过敏疾病研究的一个具有里程碑意义的流行病学研究。
通过电话联系验证和评估 ISAAC 书面特应性皮炎问卷（WAEQ）在 6 至 7 岁儿童中的适用性和可重复性。
通过对 6 至 7 岁儿童监护人进行访谈，使用 ISAAC 特应性皮炎模块问卷进行观察性研究，该问卷在 2 周内分为三个不同阶段进行：第一和第三次接触采用电话访谈，第二次接触采用现场访谈并由监督人员监督。通过 Kappa 指数评估可重复性，通过灵敏度和特异性系数评估验证。
共分析了 88 名儿童（32 名来自特应性皮炎组）的数据。对于“反复瘙痒性病变”和“病变位于典型部位”这两个问题，可重复性表现出几乎完美的一致性（Kappa 值在 0.81-0.82 之间），而对于所有其他指标，一致性均为高度一致（Kappa 值在 0.66 到 0.78 之间）。验证表明，除了与慢性和医学诊断相关的问题（分别为 34.4%和 40.6%）外，所有问题的特异性（≥80.4%）和敏感性（≥87.5%）均较高。
非随机选择、未进行样本量计算、参与者来自三级医院以及研究期间恰逢冠状病毒大流行。
我们的研究结果表明，ISAAC 特应性皮炎模块问卷通过电话访谈具有良好的可重复性，与特应性皮炎的临床诊断具有高度一致性。它可能是儿童特应性皮炎流行病学研究的一种合适的替代工具，尤其是在社会隔离期间。
