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头颈部游离皮瓣手术后 ICU 与非 ICU 术后护理的比较:系统评价和荟萃分析。

Postoperative care in ICU versus non-ICU after head and neck free-flap surgery: a systematic review and meta-analysis.

机构信息

Department of Dental Implantology, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, China

Sun Yat-Sen University, Guangzhou, Guangdong, China.

出版信息

BMJ Open. 2022 Jan 6;12(1):e053667. doi: 10.1136/bmjopen-2021-053667.

Abstract

OBJECTIVE

Admission to the intensive care unit (ICU) has long been considered as routine by most head and neck surgeons after microvascular free-flap transfer. This study aimed to answer the question 'Is there a difference in the flap survival and postoperative complications rates between admission to intensive care unit (ICU) versus Non-ICU following microvascular head and neck reconstructive surgery?'.

DESIGN

Systematic review, and meta-analysis.

METHODS

The PubMed, Embase, Scopus and Cochrane Library electronic databases were systematically searched (till April 2021) to identify the relevant studies. Studies that compared postoperative nursing of patients who underwent microvascular head and neck reconstructive surgery in ICU and non-ICU were included. The outcome variables were flap failure and length of hospital stay (LOS) and other complications. Weighted OR or mean differences with 95% CIs were calculated.

RESULTS

Eight studies involving a total of 2349 patients were included. No statistically significant differences were observed between ICU and non-ICU admitted patients regarding flap survival reported (fixed, risk ratio, 1.46; 95% CI 0.80 to 2.69, p=0.231, I=0%), reoperation, readmission, respiratory failure, delirium and mortality (p>0.05). A significant increase in the postoperative pneumonia (p=0.018) and sepsis (p=0.033) was observed in patients admitted to ICU compared with non-ICU setting.

CONCLUSION

This meta-analysis showed that an immediate postoperative nursing in the ICU after head and neck microvascular reconstructive surgery did not reduce the incidence of flap failure or complications rate. Limiting the routine ICU admission to the carefully selected patients may result in a reduction in the incidence of postoperative pneumonia, sepsis, LOS and total hospital charge.

摘要

目的

大多数头颈部外科医生在进行游离皮瓣移植后,长期以来一直将入住重症监护病房(ICU)视为常规。本研究旨在回答“在头颈部显微血管重建手术后入住 ICU 与非 ICU 对皮瓣存活率和术后并发症发生率是否有差异?”这一问题。

设计

系统回顾和荟萃分析。

方法

系统检索 PubMed、Embase、Scopus 和 Cochrane 图书馆电子数据库(截至 2021 年 4 月)以确定相关研究。纳入比较 ICU 和非 ICU 中接受头颈部显微血管重建手术患者术后护理的研究。观察指标为皮瓣失败和住院时间(LOS)及其他并发症。计算加权 OR 或均数差值及其 95%置信区间。

结果

纳入 8 项共 2349 例患者的研究。在报告的皮瓣存活率方面,ICU 和非 ICU 入院患者之间无统计学差异(固定效应,风险比 1.46;95%置信区间 0.80 至 2.69,p=0.231,I=0%)、再次手术、再入院、呼吸衰竭、谵妄和死亡率(p>0.05)。与非 ICU 相比,入住 ICU 的患者术后肺炎(p=0.018)和脓毒症(p=0.033)发生率显著增加。

结论

本荟萃分析表明,头颈部显微血管重建手术后在 ICU 进行即刻术后护理并未降低皮瓣失败或并发症发生率。限制常规 ICU 入院至精心挑选的患者可能会降低术后肺炎、脓毒症、LOS 和总住院费用的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9dc/8739421/ead51558b06b/bmjopen-2021-053667f01.jpg

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