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日常实践中指标的使用以及对银屑病相关合并症的认知:研究与现实世界之间的差异

The Use of Metrics in Daily Practice and the Perception of Psoriasis-Associated Comorbidities: Discrepancies Between Research and Real-World.

作者信息

Hillary Tom, Lambert Jo

机构信息

Department of Dermatology, University Hospitals Leuven, Leuven, 3000, Belgium.

Department of Dermatology, Ghent University Hospital, Gent, 9000, Belgium.

出版信息

Psoriasis (Auckl). 2021 Dec 21;11:169-175. doi: 10.2147/PTT.S341215. eCollection 2021.

DOI:10.2147/PTT.S341215
PMID:34993128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8710531/
Abstract

OBJECTIVE

To assess the feasibility of the future implementation of a recently published Belgian treat-to-target scoring in daily practice, we investigated to what extent Belgian dermatologists use metrics and take comorbidities into account in the follow-up of psoriasis patients.

METHODS

Belgian dermatologists were addressed to fill out an online questionnaire in April 2020.

RESULTS

A total of 149 dermatologists completed the survey. About 55% (n = 78) indicated to do a full-body examination during every visit. Psoriasis Area Severity Index (PASI) was the most frequently used clinical score: 25% (n = 35) and 61% (n = 87) indicated to use it every visit or sometimes (>1/year), respectively. The most frequently used patient-reported outcome scoring system was the Dermatology Life Quality Index: 35% use it sometimes. Overall, there is awareness for the association with metabolic syndrome.

CONCLUSION

Among tools for follow-up on moderate-to-severe psoriasis patients, Belgian dermatologists most frequently apply full-body examination and PASI score. Patient-reported outcome scoring systems are used infrequently. Psoriasis is perceived as a disease with comorbidities beyond the skin, especially obesity and hypertension. These real-world data on the use of clinical scores and PROs indicate a discrepancy from the academic setting in which new drugs are developed and evaluated. Furthermore, these data are imperative to estimate the feasibility of implementing a treat-to-target strategy published earlier by a Belgian expert group.

摘要

目的

为评估近期发表的比利时达标治疗评分在日常实践中未来实施的可行性,我们调查了比利时皮肤科医生在银屑病患者随访中使用指标以及考虑合并症的程度。

方法

2020年4月邀请比利时皮肤科医生填写一份在线问卷。

结果

共有149名皮肤科医生完成了调查。约55%(n = 78)表示每次就诊时都会进行全身检查。银屑病面积和严重程度指数(PASI)是最常用的临床评分:分别有25%(n = 35)和61%(n = 87)表示每次就诊或有时(>每年1次)使用该评分。最常用的患者报告结局评分系统是皮肤病生活质量指数:35%的人有时使用。总体而言,对与代谢综合征的关联有认识。

结论

在中重度银屑病患者的随访工具中,比利时皮肤科医生最常应用全身检查和PASI评分。患者报告结局评分系统使用较少。银屑病被视为一种除皮肤外还伴有合并症的疾病,尤其是肥胖和高血压。这些关于临床评分和患者报告结局使用情况的真实世界数据表明,与新药研发和评估的学术环境存在差异。此外,这些数据对于评估实施比利时专家组 earlier 发表的达标治疗策略的可行性至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46a/8710531/5965a0f7554f/PTT-11-169-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46a/8710531/c684d472ce6d/PTT-11-169-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46a/8710531/5965a0f7554f/PTT-11-169-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46a/8710531/c684d472ce6d/PTT-11-169-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d46a/8710531/5965a0f7554f/PTT-11-169-g0002.jpg

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本文引用的文献

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Am J Clin Dermatol. 2020 Aug;21(4):505-511. doi: 10.1007/s40257-020-00521-3.
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A Belgian consensus on the definition of a treat-to-target outcome set in psoriasis management.比利时关于银屑病治疗目标结局集定义的共识。
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A Survey of Treatment Practices in Management of Psoriasis Patients among Dermatologists of Kerala.喀拉拉邦皮肤科医生对银屑病患者治疗方法的调查
Indian Dermatol Online J. 2019 Jul-Aug;10(4):437-440. doi: 10.4103/idoj.IDOJ_306_18.
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Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.银屑病与炎症性肠病的相关性:系统评价和荟萃分析。
JAMA Dermatol. 2018 Dec 1;154(12):1417-1423. doi: 10.1001/jamadermatol.2018.3631.
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Defining and treating moderate plaque psoriasis: a dermatologist survey.定义和治疗中度斑块状银屑病:皮肤科医生调查
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