Kelsey M C, Mann G K, Bangham A M, Milnthorpe J
J R Coll Gen Pract. 1987 Feb;37(295):56-8.
Non-specific vaginitis is a commonly diagnosed condition defined in a similar manner by most authors. Although assumed to be of infective aetiology, no single organism has yet been accepted as the primary agent. This syndrome was studied in two groups of women presenting to general practitioners or attending a family planning clinic. The two groups were of similar ages and had similar markers of sexual activity. Of the 173 women studied, 90 had symptoms. Of the symptomatic women 9.5% could be categorized as having non-specific vaginitis and 36.7% as having an alternative cause for their discharge. Gardnerella vaginalis were found to be associated with anaerobes, clue cells and staphylococci more frequently than by chance.The isolation of G. vaginalis or anaerobes was assessed for their ability to help confirm the diagnosis of non-specific vaginitis and to distinguish this from other possible pathology. In patients with clinical non-specific vaginitis, the isolation of G. vaginalis proved the most sensitive (100%) though not a very specific (77.4%) indicator, whereas anaerobes were more specific (93.2%). The presence of anaerobes was a better predictor of non-specific vaginitis (30.8%) than G. vaginalis (18.9%). It was concluded that providing laboratory facilities specifically for the isolation of G. vaginalis would be of little benefit to the general practitioner in diagnosing non-specific vaginitis since it would add to the cost of processing specimens, whereas reporting the presence of heavy growths of anaerobes provides some confirmation and adds little to the cost.
非特异性阴道炎是一种常见的诊断疾病，大多数作者对其定义方式相似。尽管推测其病因是感染性的，但尚未有一种单一病原体被公认为主要病原体。对两组到全科医生处就诊或前往计划生育诊所的女性进行了该综合征的研究。这两组女性年龄相似，性活动指标也相似。在研究的173名女性中，90名有症状。在有症状的女性中，9.5%可归类为患有非特异性阴道炎，36.7%的分泌物有其他病因。发现阴道加德纳菌与厌氧菌、线索细胞和葡萄球菌的关联比偶然情况更频繁。评估阴道加德纳菌或厌氧菌的分离情况，以确定其有助于确诊非特异性阴道炎并将其与其他可能的病理情况区分开来的能力。在临床诊断为非特异性阴道炎的患者中，阴道加德纳菌的分离被证明是最敏感的指标（100%），尽管不是非常特异（77.4%），而厌氧菌则更特异（93.2%）。厌氧菌的存在比阴道加德纳菌（18.9%）更能预测非特异性阴道炎（30.8%）。得出的结论是，专门为分离阴道加德纳菌提供实验室设施，对全科医生诊断非特异性阴道炎益处不大，因为这会增加处理标本的成本，而报告大量厌氧菌生长的情况则能提供一些确诊依据，且增加的成本很少。
