在慢性阻塞性肺疾病患者中，比较步行道长度为 20 米和 30 米对 6 分钟步行试验的影响：一项随机交叉研究。
Comparison between 20 and 30 meters in walkway length affecting the 6-minute walk test in patients with chronic obstructive pulmonary disease: A randomized crossover study.
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Medical Diagnostics Unit, Thammasat University Hospital, Pathum Thani, Thailand.
出版信息
PLoS One. 2022 Jan 7;17(1):e0262238. doi: 10.1371/journal.pone.0262238. eCollection 2022.
BACKGROUND
A 30-m walkway length for the 6-minute walk test (6MWT) is the standard recommendation established by the American Thoracic Society to assess patients with chronic obstructive pulmonary disease (COPD). This study aimed to compare between the distances of 20 and 30 m long corridor affecting 6MWT in COPD patients.
METHODS
A randomized crossover study was conducted with patients. COPD patients were randomized 1:1 to either a 20-m or a 30-m walkway in the first test, then switched to the other in the second test. Physiologic parameters and 6-minute walking distance (6MWD) were recorded.
RESULTS
Fifty subjects (92% men) were included: age 69.1±7.4 years, body mass index 22.9±5.5 kg/m2, FEV1 63.0±21.3%, and 50% having cardiovascular disease. The 6MWD in a 20-m and a 30-m walkway were 337.82±71.80 m and 359.85±77.25 m, respectively (P<0.001). Mean distance difference was 22.03 m (95% CI -28.29 to -15.76, P<0.001). Patients with a 20-m walkway had more turns than those with a 30-m walkway (mean difference of 4.88 turns, 95% CI 4.48 to 5.28, P<0.001). Also, higher systolic blood pressure was found in patients with a 20-m walkway after 6MWT (4.62 mmHg, P = 0.019). Other parameters and Borg dyspnea scale did not differ.
CONCLUSIONS
The walkway length had significant effect on walking distance in COPD patients. A 30-m walkway length should still be recommended in 6MWT for COPD assessment.
CLINICAL TRIAL REGISTRATION
Clinicaltrials.in.th number: TCTR20200206003.
背景
美国胸科学会建议使用 30 米的步行道长度进行 6 分钟步行测试（6MWT），以评估慢性阻塞性肺疾病（COPD）患者。本研究旨在比较 COPD 患者使用 20 米和 30 米走廊对 6MWT 距离的影响。
方法
这是一项采用随机交叉设计的研究，共纳入了 50 名患者。将 COPD 患者随机分为两组，一组先在 20 米长的走廊中进行测试，另一组先在 30 米长的走廊中进行测试。记录生理参数和 6 分钟步行距离（6MWD）。
结果
共纳入 50 名受试者（92%为男性），年龄 69.1±7.4 岁，体重指数 22.9±5.5 kg/m2，FEV1 63.0±21.3%，50%合并心血管疾病。在 20 米和 30 米走廊中，6MWD 分别为 337.82±71.80 m 和 359.85±77.25 m（P<0.001）。平均距离差为 22.03 m（95%CI -28.29 至 -15.76，P<0.001）。与 30 米走廊相比，20 米走廊的患者转弯次数更多（平均差 4.88 次，95%CI 4.48 至 5.28，P<0.001）。此外，20 米走廊组患者在 6MWT 后收缩压升高（4.62 mmHg，P = 0.019）。其他参数和 Borg 呼吸困难量表无差异。
结论
走廊长度对 COPD 患者的步行距离有显著影响。在 COPD 评估中，6MWT 仍应推荐使用 30 米的走廊长度。
临床试验注册号
TCTR20200206003。
Zotero 插件